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Gene Review

TFDP3  -  transcription factor Dp family, member 3

Homo sapiens

Synonyms: CT30, Cancer/testis antigen 30, DP4, E2F-like, HCA661, ...
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Disease relevance of TFDP3

  • Intracellular flow cytometry and enzyme-linked immunospot assay showed that these CTLs were able to target a hepatoma cell line, HepG2, which is HLA-A2 and HCA661 positive [1].
  • We constructed a recombinant adenovirus expressing the full-length cDNA of HCA661 gene and then transduced immature DCs, which had been generated with GM-CSF and IL-4 from peripheral blood mononuclear cell of HLA-A2(+) healthy donors [1].

High impact information on TFDP3

  • Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties [2].
  • Like the recently identified E2F-like proteins of Arabidopsis, E2F7 has two DNA binding domains and binds to the E2F DNA binding consensus site independently of DP co-factors [3].
  • Recently, several laboratories have isolated a cDNA clone that encodes an E2F-like protein, known as E2F-1 [4].
  • Using low-stringency hybridization, we have isolated cDNA clones that encode two additional E2F-like proteins, called E2F-2 and E2F-3 [4].
  • Fine mapping further revealed four amino acids in this region, which were critical for the functional conversion from activation by TFDP1 to suppression by TFDP3 [5].

Biological context of TFDP3


Anatomical context of TFDP3


Other interactions of TFDP3


  1. Transduction of dendritic cells with recombinant adenovirus encoding HCA661 activates autologous cytotoxic T lymphocytes to target hepatoma cells. Chan, R.C., Pang, X.W., Wang, Y.D., Chen, W.F., Xie, Y. Br. J. Cancer (2004) [Pubmed]
  2. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Kaelin, W.G., Krek, W., Sellers, W.R., DeCaprio, J.A., Ajchenbaum, F., Fuchs, C.S., Chittenden, T., Li, Y., Farnham, P.J., Blanar, M.A. Cell (1992) [Pubmed]
  3. E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes. Di Stefano, L., Jensen, M.R., Helin, K. EMBO J. (2003) [Pubmed]
  4. The retinoblastoma protein binds to a family of E2F transcription factors. Lees, J.A., Saito, M., Vidal, M., Valentine, M., Look, T., Harlow, E., Dyson, N., Helin, K. Mol. Cell. Biol. (1993) [Pubmed]
  5. Human TFDP3, a Novel DP Protein, Inhibits DNA Binding and Transactivation by E2F. Qiao, H., Di Stefano, L., Tian, C., Li, Y.Y., Yin, Y.H., Qian, X.P., Pang, X.W., Li, Y., McNutt, M.A., Helin, K., Zhang, Y., Chen, W.F. J. Biol. Chem. (2007) [Pubmed]
  6. G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter. Dou, Q.P., Zhao, S., Levin, A.H., Wang, J., Helin, K., Pardee, A.B. J. Biol. Chem. (1994) [Pubmed]
  7. The human POLD1 gene. Identification of an upstream activator sequence, activation by Sp1 and Sp3, and cell cycle regulation. Zhao, L., Chang, L.S. J. Biol. Chem. (1997) [Pubmed]
  8. Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies. Wang, Y., Han, K.J., Pang, X.W., Vaughan, H.A., Qu, W., Dong, X.Y., Peng, J.R., Zhao, H.T., Rui, J.A., Leng, X.S., Cebon, J., Burgess, A.W., Chen, W.F. J. Immunol. (2002) [Pubmed]
  9. Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription. Christensen, J., Cloos, P., Toftegaard, U., Klinkenberg, D., Bracken, A.P., Trinh, E., Heeran, M., Di Stefano, L., Helin, K. Nucleic Acids Res. (2005) [Pubmed]
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