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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Statistics, Nonparametric

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Disease relevance of Statistics, Nonparametric

  • Interestingly, 17 of 29 lymphoma patients with B symptoms (59%) as opposed to 3 of 28 lymphoma patients without B symptoms (11%) had detectable serum IL-6 levels (P < 0.001, chi 2 test); the median IL-6 level was 28.9 pg/ml (B symptoms present) versus undetectable (no B symptoms) (P < 0.005, Mann-Whitney U test) [1].
  • JAB1 was detected immunohistochemically in 43 of 53 (81%) tumors; 32 (60%) breast carcinomas showed high JAB1 expression (>50% of cells positive) and reduced or absent p27 levels (P = 0.02, Mann-Whitney U test) [2].
  • Recovery of spermatogenesis following treatment-induced azoospermia was significantly higher among the MOPP-2 patients (Mann-Whitney rank sum test, p = 0.001) [3].
  • (2) In 25 patients followed for 10 days after operation for Crohn's disease, there was a significant fall in fibronectin concentrations of 43% (p less than 0.01, Wilcoxon's rank-sum test) [4].
  • Median serum concentrations of VEGF in patients with vulvar cancer (n = 41) and healthy female controls (n = 130) were 260 (range, 33-1216) pg/ml and 216 (range, 0-777) pg/ml, respectively (Mann-Whitney U test, P = 0.048) [5].

Psychiatry related information on Statistics, Nonparametric


High impact information on Statistics, Nonparametric


Chemical compound and disease context of Statistics, Nonparametric


Biological context of Statistics, Nonparametric


Anatomical context of Statistics, Nonparametric


Associations of Statistics, Nonparametric with chemical compounds

  • The clinical course of the two groups, as judged by a newly designed SVT-severity scale, started to differ in favour of the heparin group after 3 days of treatment (p less than 0.05, Mann-Whitney U-test) and the difference remained significant (p less than 0.01) after 8 days of treatment [30].
  • Myocardial flows after dipyridamole, however, did not show a normal frequency distribution (Kolmogorov-Smirnov test), and two patient populations could be identified [31].
  • The in vivo antitumor effect of the cell-specific immunotoxin plus monensin emulsion was superior to immunotoxin alone or to immunotoxin plus monensin in buffer (P less than 0.03; Mann-Whitney U test) [32].
  • BrdUrd-labeled 6TG-resistant cells were enumerated flow cytometrically using fluorescent microspheres as an internal standard and the nonparametric, Kolmogorov-Smirnov test was used for independent statistical analysis of the subpopulations of fluorescent, 6TG-resistant cells [33].
  • After clonidine administration, growth hormone rose in PSP subjects (median increase 4.3; interquartile range 1.8-7.8 mU/l) and controls, unlike MSA subjects (0.9; 0.3-2.4 mU/l; P < 0.005, Mann-Whitney U-test) [34].

Gene context of Statistics, Nonparametric

  • Associations between RR, PFI, and primary tumor characteristics including ER, PgR, and AR levels were examined using the Mann-Whitney U test, Kaplan-Meier product-limit estimator, and Cox proportional hazards regression, as appropriate [35].
  • There was a statistically significant difference between the slope value of VEGF-positive tumors and that of VEGF-negative tumors (Mann-Whitney U test, P <.0001) [36].
  • Mann-Whitney rank sum test was applied to compare the expression amounts of different mucin genes in tissues [37].
  • Moreover, DNA adducts were also raised in workers without GSTM1 activity (GSTM1-null genotype) (Mann-Whitney U-test, z = 2.25, P = 0.0246) [38].
  • The Mann-Whitney U test was used to compare the median mRNA copy numbers of the symptomatic with the asymptomatic carriers of the mutant PRPF31 allele [39].

Analytical, diagnostic and therapeutic context of Statistics, Nonparametric


  1. Serum interleukin 6 levels are elevated in lymphoma patients and correlate with survival in advanced Hodgkin's disease and with B symptoms. Kurzrock, R., Redman, J., Cabanillas, F., Jones, D., Rothberg, J., Talpaz, M. Cancer Res. (1993) [Pubmed]
  2. Jun activation domain-binding protein 1 expression in breast cancer inversely correlates with the cell cycle inhibitor p27(Kip1). Kouvaraki, M.A., Rassidakis, G.Z., Tian, L., Kumar, R., Kittas, C., Claret, F.X. Cancer Res. (2003) [Pubmed]
  3. Recovery of spermatogenesis after treatment for Hodgkin's disease: limiting dose of MOPP chemotherapy. da Cunha, M.F., Meistrich, M.L., Fuller, L.M., Cundiff, J.H., Hagemeister, F.B., Velasquez, W.S., McLaughlin, P., Riggs, S.A., Cabanillas, F.F., Salvador, P.G. J. Clin. Oncol. (1984) [Pubmed]
  4. Plasma fibronectin in Crohn's disease. Allan, A., Wyke, J., Allan, R.N., Morel, P., Robinson, M., Scott, D.L., Alexander-Williams, J. Gut (1989) [Pubmed]
  5. Serum concentrations of vascular endothelial growth factor in vulvar cancer. Hefler, L., Tempfer, C., Obermair, A., Frischmuth, K., Sliutz, G., Reinthaller, A., Leodolter, S., Kainz, C. Clin. Cancer Res. (1999) [Pubmed]
  6. Auditory event-related potentials, auditory digit span, and clinical symptoms in chronic schizophrenic men on neuroleptic medication. Stefánsson, S.B., Jónsdóttir, T.J. Biol. Psychiatry (1996) [Pubmed]
  7. Guanfacine treatment of cognitive impairment in schizophrenia. Friedman, J.I., Adler, D.N., Temporini, H.D., Kemether, E., Harvey, P.D., White, L., Parrella, M., Davis, K.L. Neuropsychopharmacology (2001) [Pubmed]
  8. St. John's wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy. Laakmann, G., Schüle, C., Baghai, T., Kieser, M. Pharmacopsychiatry (1998) [Pubmed]
  9. Cell mediated immunity and alcohol intake in Antarctic wintering personnel. Thom, O., Lugg, D.J. International journal of circumpolar health. (2002) [Pubmed]
  10. Genotype-phenotype relationships in U.S. melanoma-prone families with CDKN2A and CDK4 mutations. Goldstein, A.M., Struewing, J.P., Chidambaram, A., Fraser, M.C., Tucker, M.A. J. Natl. Cancer Inst. (2000) [Pubmed]
  11. Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma. Gasparini, G., Toi, M., Gion, M., Verderio, P., Dittadi, R., Hanatani, M., Matsubara, I., Vinante, O., Bonoldi, E., Boracchi, P., Gatti, C., Suzuki, H., Tominaga, T. J. Natl. Cancer Inst. (1997) [Pubmed]
  12. Chronomodulated versus fixed-infusion-rate delivery of ambulatory chemotherapy with oxaliplatin, fluorouracil, and folinic acid (leucovorin) in patients with colorectal cancer metastases: a randomized multi-institutional trial. Lévi, F.A., Zidani, R., Vannetzel, J.M., Perpoint, B., Focan, C., Faggiuolo, R., Chollet, P., Garufi, C., Itzhaki, M., Dogliotti, L. J. Natl. Cancer Inst. (1994) [Pubmed]
  13. Vitamin A supplementation and plasma retinol levels: a randomized trial among women. Willett, W.C., Stampfer, M.J., Underwood, B.A., Sampson, L.A., Hennekens, C.H., Wallingford, J.C., Cooper, L., Hsieh, C.C., Speizer, F.E. J. Natl. Cancer Inst. (1984) [Pubmed]
  14. Randomised comparison of thalidomide versus placebo in toxic epidermal necrolysis. Wolkenstein, P., Latarjet, J., Roujeau, J.C., Duguet, C., Boudeau, S., Vaillant, L., Maignan, M., Schuhmacher, M.H., Milpied, B., Pilorget, A., Bocquet, H., Brun-Buisson, C., Revuz, J. Lancet (1998) [Pubmed]
  15. Double-blind, placebo-controlled study of nicergoline in the treatment of pruritus in patients receiving maintenance hemodialysis. Bousquet, J., Rivory, J.P., Maheut, M., Michel, F.B., Mion, C. J. Allergy Clin. Immunol. (1989) [Pubmed]
  16. Improvement of quality of life by treatment with cetirizine in patients with perennial allergic rhinitis as determined by a French version of the SF-36 questionnaire. Bousquet, J., Duchateau, J., Pignat, J.C., Fayol, C., Marquis, P., Mariz, S., Ware, J.E., Valentin, B., Burtin, B. J. Allergy Clin. Immunol. (1996) [Pubmed]
  17. A placebo-controlled, double-blind, cross-over trial of flunarizine in common migraine. Sørensen, P.S., Hansen, K., Olesen, J. Cephalalgia : an international journal of headache. (1986) [Pubmed]
  18. Glutathione and glutathione-related enzymes in decidua and placenta of controls and women with pre-eclampsia. Knapen, M.F., Peters, W.H., Mulder, T.P., Merkus, H.M., Jansen, J.B., Steegers, E.A. Placenta (1999) [Pubmed]
  19. Fluorimetric assay of D-lactate. McLellan, A.C., Phillips, S.A., Thornalley, P.J. Anal. Biochem. (1992) [Pubmed]
  20. p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer. Kim, D.H., Nelson, H.H., Wiencke, J.K., Zheng, S., Christiani, D.C., Wain, J.C., Mark, E.J., Kelsey, K.T. Cancer Res. (2001) [Pubmed]
  21. Serotonin transporter promoter variants in autism: functional effects and relationship to platelet hyperserotonemia. Anderson, G.M., Gutknecht, L., Cohen, D.J., Brailly-Tabard, S., Cohen, J.H., Ferrari, P., Roubertoux, P.L., Tordjman, S. Mol. Psychiatry (2002) [Pubmed]
  22. Estrogen improves motor disability in parkinsonian postmenopausal women with motor fluctuations. Tsang, K.L., Ho, S.L., Lo, S.K. Neurology (2000) [Pubmed]
  23. Oculomotor testing in the differential diagnosis of degenerative ataxic disorders. Wessel, K., Moschner, C., Wandinger, K.P., Kömpf, D., Heide, W. Arch. Neurol. (1998) [Pubmed]
  24. Maternal pregnancy hormone levels in an area with a high incidence (Boston, USA) and in an area with a low incidence (Shanghai, China) of breast cancer. Lipworth, L., Hsieh, C.C., Wide, L., Ekbom, A., Yu, S.Z., Yu, G.P., Xu, B., Hellerstein, S., Carlstrom, K., Trichopoulos, D., Adami, H.O. Br. J. Cancer (1999) [Pubmed]
  25. Cyclohexyl adenosine protects against neuronal death following ischemia in the CA1 region of gerbil hippocampus. von Lubitz, D.K., Dambrosia, J.M., Kempski, O., Redmond, D.J. Stroke (1988) [Pubmed]
  26. Enhanced expression of neutral endopeptidase (NEP) in airway epithelium in biopsies from steroid- versus nonsteroid-treated patients with atopic asthma. Sont, J.K., van Krieken, J.H., van Klink, H.C., Roldaan, A.C., Apap, C.R., Willems, L.N., Sterk, P.J. Am. J. Respir. Cell Mol. Biol. (1997) [Pubmed]
  27. Basophil mediator release in atopic dermatitis. Bull, H.A., Courtney, P.F., Bunker, C.B., Rustin, M.H., Pearce, F.L., Dowd, P.M. J. Invest. Dermatol. (1993) [Pubmed]
  28. Relationship of CD4 counts to neurophysiological function in HIV-1--infected homosexual men. Boccellari, A.A., Dilley, J.W., Yingling, C.D., Chambers, D.B., Tauber, M.A., Moss, A.R., Osmond, D.H. Arch. Neurol. (1993) [Pubmed]
  29. Analysis of relative proliferation rates of Wilms' tumor components using proliferating cell nuclear antigen and MIB-1 (Ki-67 equivalent antigen) immunostaining and assessment of mitotic index. Khine, M.M., Aung, W., Sibbons, P.D., Howard, C.V., Clapham, E., McGill, F., Van Velzen, D. Lab. Invest. (1994) [Pubmed]
  30. Heparin treatment in sinus venous thrombosis. Einhäupl, K.M., Villringer, A., Meister, W., Mehraein, S., Garner, C., Pellkofer, M., Haberl, R.L., Pfister, H.W., Schmiedek, P. Lancet (1991) [Pubmed]
  31. Coronary reserve and exercise ECG in patients with chest pain and normal coronary angiograms. Camici, P.G., Gistri, R., Lorenzoni, R., Sorace, O., Michelassi, C., Bongiorni, M.G., Salvadori, P.A., L'Abbate, A. Circulation (1992) [Pubmed]
  32. Monensin in lipid emulsion for the potentiation of ricin A chain immunotoxins. Griffin, T., Raso, V. Cancer Res. (1991) [Pubmed]
  33. Flow cytometric enumeration of drug-resistant tumor cells. deFazio, A., Musgrove, E.A., Tattersall, M.H. Cancer Res. (1988) [Pubmed]
  34. Physiological, pharmacological and neurohormonal assessment of autonomic function in progressive supranuclear palsy. Kimber, J., Mathias, C.J., Lees, A.J., Bleasdale-Barr, K., Chang, H.S., Churchyard, A., Watson, L. Brain (2000) [Pubmed]
  35. Medroxyprogesterone acetate therapy in advanced breast cancer: the predictive value of androgen receptor expression. Birrell, S.N., Roder, D.M., Horsfall, D.J., Bentel, J.M., Tilley, W.D. J. Clin. Oncol. (1995) [Pubmed]
  36. Small peripheral pulmonary carcinomas evaluated with dynamic MR imaging: correlation with tumor vascularity and prognosis. Fujimoto, K., Abe, T., Müller, N.L., Terasaki, H., Kato, S., Sadohara, J., Kono, R., Edamitsu, O., Ishitake, T., Hayashi, A., Rikimaru, T., Hayabuchi, N. Radiology. (2003) [Pubmed]
  37. Quantitative analysis of mRNA encoding MUC1, MUC2, and MUC5AC genes: a correlation between specific mucin gene expression and sialomucin expression in non-small cell lung cancer. Yu, C.J., Shew, J.Y., Shun, C.T., Lin, H.T., Kuo, S.H., Luh, K.T., Yang, P.C. Am. J. Respir. Cell Mol. Biol. (1998) [Pubmed]
  38. Reduced nucleotide excision repair and GSTM1-null genotypes influence anti-B[a]PDE-DNA adduct levels in mononuclear white blood cells of highly PAH-exposed coke oven workers. Pavanello, S., Pulliero, A., Siwinska, E., Mielzynska, D., Clonfero, E. Carcinogenesis (2005) [Pubmed]
  39. Expression of PRPF31 mRNA in patients with autosomal dominant retinitis pigmentosa: a molecular clue for incomplete penetrance? Vithana, E.N., Abu-Safieh, L., Pelosini, L., Winchester, E., Hornan, D., Bird, A.C., Hunt, D.M., Bustin, S.A., Bhattacharya, S.S. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  40. The relationship between TP53 mutations and overexpression of p53 and prognosis in malignant gliomas of childhood. Pollack, I.F., Hamilton, R.L., Finkelstein, S.D., Campbell, J.W., Martinez, A.J., Sherwin, R.N., Bozik, M.E., Gollin, S.M. Cancer Res. (1997) [Pubmed]
  41. Elevated plasma osteopontin in metastatic breast cancer associated with increased tumor burden and decreased survival. Singhal, H., Bautista, D.S., Tonkin, K.S., O'Malley, F.P., Tuck, A.B., Chambers, A.F., Harris, J.F. Clin. Cancer Res. (1997) [Pubmed]
  42. The behavioural importance of dynamically activated descending inhibition from the nucleus reticularis gigantocellularis pars alpha. Azami, J., Green, D.L., Roberts, M.H., Monhemius, R. Pain (2001) [Pubmed]
  43. Inhibition of rostral basal forebrain neurons promotes wakefulness and induces FOS in orexin neurons. Satoh, S., Matsumura, H., Nakajima, T., Nakahama, K., Kanbayashi, T., Nishino, S., Yoneda, H., Shigeyoshi, Y. Eur. J. Neurosci. (2003) [Pubmed]
  44. A phase 2 study of radio frequency interstitial tissue ablation of localized renal tumors. Walther, M.C., Shawker, T.H., Libutti, S.K., Lubensky, I., Choyke, P.L., Venzon, D., Linehan, W.M. J. Urol. (2000) [Pubmed]
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