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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Spsb2  -  splA/ryanodine receptor domain and SOCS...

Mus musculus

Synonyms: AI461677, C9, Gene-rich cluster protein C9, Grcc9, SPRY domain-containing SOCS box protein 2, ...
 
 
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Disease relevance of Spsb2

 

High impact information on Spsb2

  • SSB-2 expression was observed in the kidney and in megakaryocytes, a finding consistent with the phenotype of mice lacking this gene [1].
  • Tissue histology and other hematological parameters were normal, as was the majority of serum biochemistry, with the exception that blood urea nitrogen (BUN) levels were decreased in mice lacking SSB-2 [1].
  • The optimal receptor potency of ryanodine and didehydroryanodine is reduced 3-14-fold by hydroxylation at an isopropyl methyl substituent, epimerization at C9, oxidation or acetylation of the C10-hydroxyl, or epoxidation at the 9,21-position; other ryanoids are less active [2].

References

  1. Genetic deletion of murine SPRY domain-containing SOCS box protein 2 (SSB-2) results in very mild thrombocytopenia. Masters, S.L., Palmer, K.R., Stevenson, W.S., Metcalf, D., Viney, E.M., Sprigg, N.S., Alexander, W.S., Nicola, N.A., Nicholson, S.E. Mol. Cell. Biol. (2005) [Pubmed]
  2. Structural aspects of ryanodine action and selectivity. Waterhouse, A.L., Pessah, I.N., Francini, A.O., Casida, J.E. J. Med. Chem. (1987) [Pubmed]
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