The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SYT6  -  synaptotagmin VI

Homo sapiens

Synonyms: Synaptotagmin VI, Synaptotagmin-6, SytVI
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on SYT6


Biological context of SYT6

  • Calcium-triggered acrosomal exocytosis in permeabilized sperm cells was abrogated by a specific anti-synaptotagmin VI antibody, indicating that the protein is required for the process [3].

Associations of SYT6 with chemical compounds

  • Moreover, a recombinant fusion protein between glutathione S-transferase and the two calcium and phospholipid binding domains of synaptotagmin VI completely inhibited calcium-triggered exocytosis [3].

Analytical, diagnostic and therapeutic context of SYT6


  1. Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis. Roggero, C.M., Tomes, C.N., De Blas, G.A., Castillo, J., Michaut, M.A., Fukuda, M., Mayorga, L.S. Dev. Biol. (2005) [Pubmed]
  2. SNARE complex assembly is required for human sperm acrosome reaction. Tomes, C.N., Michaut, M., De Blas, G., Visconti, P., Matti, U., Mayorga, L.S. Dev. Biol. (2002) [Pubmed]
  3. Synaptotagmin VI participates in the acrosome reaction of human spermatozoa. Michaut, M., De Blas, G., Tomes, C.N., Yunes, R., Fukuda, M., Mayorga, L.S. Dev. Biol. (2001) [Pubmed]
WikiGenes - Universities