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Gene Review

STP-A11  -  saimiri transformation-associated protein

Saimiriine herpesvirus 2

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Disease relevance of STP-A11


High impact information on STP-A11


Associations of STP-A11 with chemical compounds

  • Mutational analysis of STP-A11 showed that binding to src kinase required the tyrosine residue at 115, showing that YAEV/I is a likely binding motif for src [5].


  1. Primary structure of the herpesvirus saimiri genome. Albrecht, J.C., Nicholas, J., Biller, D., Cameron, K.R., Biesinger, B., Newman, C., Wittmann, S., Craxton, M.A., Coleman, H., Fleckenstein, B. J. Virol. (1992) [Pubmed]
  2. Herpesvirus saimiri-encoded proteins Tip and StpC modulate human immunodeficiency virus type 1 replication in T-cell lines and lymphocytes independently of viral tropism. Raymond, A.D., Hasham, M.G., Tsygankov, A.Y., Henderson, E.E. Virology (2004) [Pubmed]
  3. Herpesvirus saimiri terminal membrane proteins modulate HIV-1 replication by altering Nef and Tat functions. Raymond, A.D., Hasham, M., Tsygankov, A.Y., Henderson, E.E. Curr. HIV Res. (2007) [Pubmed]
  4. Identification of transforming genes of subgroup A and C strains of Herpesvirus saimiri. Jung, J.U., Trimble, J.J., King, N.W., Biesinger, B., Fleckenstein, B.W., Desrosiers, R.C. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  5. Genetic variation of herpesvirus saimiri subgroup A transforming protein and its association with cellular src. Lee, H., Trimble, J.J., Yoon, D.W., Regier, D., Desrosiers, R.C., Jung, J.U. J. Virol. (1997) [Pubmed]
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