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Gene Review:

M - E1 glycoprotein

Murine hepatitis virus strain A59

Rottier, P. et al., Mayer, T. et al., Armstrong, J. et al., Tooze, J. et al., Talbot, P.J. et al., et al.

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Disease relevance of M

We have therefore used the E1 glycoprotein from coronavirus MHV-A59 as a viral model for this class of protein [1].
Assembly in vitro of a spanning membrane protein of the endoplasmic reticulum: the E1 glycoprotein of coronavirus mouse hepatitis virus A59 [2].
Within the sac- syncitia the viral E1 glycoprotein accumulates in the RER and many virions assemble there [3].

High impact information on M

Sequence and topology of a model intracellular membrane protein, E1 glycoprotein, from a coronavirus [1].
The E1 glycoprotein of coronavirus mouse hepatitis virus A59 was synthesized in vitro by translation of viral mRNA in the presence of dog pancreatic microsomes [2].
The E1-glycoprotein (Mr = 26,014; 228 amino acids) of mouse hepatitis virus A59 is a class III membrane glycoprotein which has been used in this study as a model system in the study of membrane integration and protein transport [4].
Colonized mice often had pre-existing MHV antibodies directed against epitopes on the E2 glycoprotein, the E1 glycoprotein, and the nucleocapsid protein [5].
Following labelling for the E1 glycoprotein we see a periodic fine structure, rows of "beads" with a centre to centre spacing of about 7.5 nm, in the region between the paired membranes [6].

References

Sequence and topology of a model intracellular membrane protein, E1 glycoprotein, from a coronavirus. Armstrong, J., Niemann, H., Smeekens, S., Rottier, P., Warren, G. Nature (1984) [Pubmed]
Assembly in vitro of a spanning membrane protein of the endoplasmic reticulum: the E1 glycoprotein of coronavirus mouse hepatitis virus A59. Rottier, P., Brandenburg, D., Armstrong, J., van der Zeijst, B., Warren, G. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
Infection of AtT20 murine pituitary tumour cells by mouse hepatitis virus strain A59: virus budding is restricted to the Golgi region. Tooze, J., Tooze, S.A. Eur. J. Cell Biol. (1985) [Pubmed]
Membrane integration and intracellular transport of the coronavirus glycoprotein E1, a class III membrane glycoprotein. Mayer, T., Tamura, T., Falk, M., Niemann, H. J. Biol. Chem. (1988) [Pubmed]
Epitope-specific antibody response to murine hepatitis virus-4 (strain JHM). Talbot, P.J., Salmi, A.A., Knobler, R.L., Buchmeier, M.J. J. Immunol. (1985) [Pubmed]
Laminated cisternae of the rough endoplasmic reticulum induced by coronavirus MHV-A59 infection. Tooze, J., Tooze, S.A., Warren, G. Eur. J. Cell Biol. (1985) [Pubmed]

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