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Gene Review

WFDC5  -  WAP four-disulfide core domain 5

Homo sapiens

Synonyms: PRG5, UNQ3036/PRO9842, WAP four-disulfide core domain protein 5, WAP1, dJ211D12.5, ...
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High impact information on WFDC5

  • WAP1 is located on chromosome 5 in wheat and, by synteny with other cereal genomes, is likely to be collocated with Vrn-1 [1].
  • [Yan, L., Loukoianov, A., Tranquilli, G., Helguera, M., Fahima, T. & Dubcovsky, J. (2003) Proc. Natl. Acad. Sci. USA 100, 6263-6268] in the diploid wheat progenitor Triticum monococcum that WAP1 (TmAP1) corresponds to the Vrn-1 gene [1].
  • Based on the results reported herein, we suggest that YC-1 induces cell cycle arrest and inhibits tumor growth both in vitro and in vivo via the up-regulation of p21(CIP1/WAP1) expression in HA22T cells [2].
  • MCF-7 cells were stably transfected with the hWAP/hGH (human growth hormone) fusion gene, cultured on Matrigel, and treated with lactogenic hormones [3].


  1. MADS box genes control vernalization-induced flowering in cereals. Trevaskis, B., Bagnall, D.J., Ellis, M.H., Peacock, W.J., Dennis, E.S. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells. Wang, S.W., Pan, S.L., Guh, J.H., Chen, H.L., Huang, D.M., Chang, Y.L., Kuo, S.C., Lee, F.Y., Teng, C.M. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  3. Analysis of the promoter of mutated human whey acidic protein (WAP) gene. Nukumi, N., Seki, M., Iwamori, T., Yada, T., Naito, K., Tojo, H. J. Reprod. Dev. (2006) [Pubmed]
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