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Gene Review

NFAM1  -  NFAT activating protein with ITAM motif 1

Homo sapiens

Synonyms: CNAIP, Calcineurin/NFAT-activating ITAM-containing protein, NFAT activation molecule 1, NFAT-activating protein with ITAM motif 1, bK126B4.4
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High impact information on NFAM1

  • The results suggest that NFAM1 modulates B cell signaling through its ITAM, which regulates B cell development [1].
  • NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling [1].
  • By using this strategy, NFAT activating molecule 1 (NFAM1) was cloned as an immunoreceptor tyrosine-based activation motif (ITAM)-bearing cell surface molecule belonging to the Ig superfamily and is predominantly expressed in spleen B and T cells [1].
  • Mutation of either or both tyrosines in the ITAM abolished transcriptional activation induced by CNAIP, indicating that the ITAM is indispensable for CNAIP function in activating cytokine gene promoters [2].
  • Quantitative reverse transcription-PCR showed that CNAIP was preferentially expressed in neutrophils, monocytes, mast cells, and other immune-related cells [2].

Biological context of NFAM1

  • Co-transfection of CNAIP expression constructs with luciferase reporter plasmids in HMC-1 cells resulted in activation of interleukin-13 and tumor necrosis factor-alpha promoters, which was mediated through the calcineurin/NFAT-signaling pathway [2].


  1. NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling. Ohtsuka, M., Arase, H., Takeuchi, A., Yamasaki, S., Shiina, R., Suenaga, T., Sakurai, D., Yokosuka, T., Arase, N., Iwashima, M., Kitamura, T., Moriya, H., Saito, T. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Calcineurin/nuclear factors of activated T cells (NFAT)-activating and immunoreceptor tyrosine-based activation motif (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway. Yang, J., Hu, G., Wang, S.W., Li, Y., Martin, R., Li, K., Yao, Z. J. Biol. Chem. (2003) [Pubmed]
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