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Gene Review

PROM2  -  prominin 2

Homo sapiens

Synonyms: PROM-2, PROML2, Prominin-2, Prominin-like protein 2, UNQ2521/PRO6014, ...
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Disease relevance of PROM2

  • However, in contrast to prominin-1, prominin-2 was not detected in the eye, which perhaps explains why a loss-of function mutation in the human prominin-1 gene causes retinal degeneration but no other obvious pathological signs [1].

High impact information on PROM2

  • Consistent with this, prominin-2 shows a similar tissue distribution to prominin-1, being highly expressed in the adult kidney and detected all along the digestive tract as well as in various other epithelial tissues [1].
  • Here we report the identification as well as molecular and cell biological characterization of mouse, rat, and human prominin-2, a 112-kDa glycoprotein structurally related to prominin (referred to as prominin-1) [1].
  • Upon its ectopic expression in Chinese hamster ovary cells as a green fluorescent protein fusion chimera, prominin-2 was also found to be associated with plasma membrane protrusions, as revealed by its co-localization with prominin-1, suggesting a related role [1].
  • Although the amino acid identity between prominin-2 and prominin-1 is low (<30%), their genomic organization is strikingly similar, suggesting an early gene duplication event [1].


  1. Characterization of prominin-2, a new member of the prominin family of pentaspan membrane glycoproteins. Fargeas, C.A., Florek, M., Huttner, W.B., Corbeil, D. J. Biol. Chem. (2003) [Pubmed]
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