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Gene Review

PROM1  -  prominin 1

Homo sapiens

Synonyms: AC133, Antigen AC133, CD133, CORD12, MCDR2, ...
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Disease relevance of PROM1


Psychiatry related information on PROM1


High impact information on PROM1

  • Subtracting the Math: prominin-positive cerebellar stem cells in white matter [9].
  • Here we report that a subpopulation of circulating cells expressing AC133, a well-characterized marker of hematopoietic stem cells, also expresses early myogenic markers [10].
  • Freshly isolated, circulating AC133(+) cells were induced to undergo myogenesis when cocultured with myogenic cells or exposed to Wnt-producing cells in vitro and when delivered in vivo through the arterial circulation or directly into the muscles of transgenic scid/mdx mice (which allow survival of human cells) [10].
  • Human circulating AC133(+) stem cells restore dystrophin expression and ameliorate function in dystrophic skeletal muscle [10].
  • Here, we further dissected the ALDH(hi)-Lin- population by selection for CD133, a surface molecule expressed on progenitors from hematopoietic, endothelial, and neural lineages [11].

Chemical compound and disease context of PROM1


Biological context of PROM1

  • Here, we demonstrate, by using a novel prominin-1 antiserum (alphahE2), that the decrease of AC133 immunoreactivity observed during differentiation of the colonic adenocarcinoma-derived Caco-2 cells is not paralleled by a down-regulation of prominin-1 [3].
  • These observations suggest that only the AC133 epitope is down-regulated upon cell differentiation [3].
  • Under defined serum-free conditions, the growth factors requirements, proliferation, and differentiation capacity of muscle and neural hematopoiesis were distinct to that derived from committed hematopoietic sites and were uniquely restricted to CD45(-)CD34(-) cells expressing the prominin AC133 [17].
  • The primary outcome measurement was change in physical impairments thought to be secondary to radiation, including active and passive range of motion (AROM and PROM), muscle strength, limb edema, and pain [12].
  • Moreover, valproic acid treatment increases histone H4 acetylation levels at specific regulatory sites on HOXB4, a transcription factor gene with a key role in the regulation of HSC self-renewal and AC133, a recognized marker gene for stem cell populations [18].

Anatomical context of PROM1


Associations of PROM1 with chemical compounds


Regulatory relationships of PROM1


Other interactions of PROM1

  • These adherent cells did not express CD34 or CD133 antigens on their surface, nor did they express markers for endothelial, mesenchymal, or dendritic cells [4].
  • Subsequent isolation and plating of nonadherent FL-derived VEGFR-2(+) cells with VEGF and FGF-2 resulted in differentiation of AC133(+ )VEGFR-2(+) cells into adherent AC133(-)VEGFR-2(+)Ac-LDL(+ )(acetylated low-density lipoprotein) colonies (plating efficiency of 3%) [26].
  • EPCs labeled with CD34, CD133, and vascular endothelial growth factor receptor-2 (VEGFR2) antibodies were counted by flow cytometry in the peripheral blood of 53 NSCLC patients [27].
  • CD45 and CD14 decreased, while CD34 and the progenitor-cell marker CD133 remained strongly expressed [28].
  • Suppression of the growth of AC133/CD133 positive stem cells might be considered as one of the therapeutic targets for VHL-associated hemangioblastoma [24].

Analytical, diagnostic and therapeutic context of PROM1


  1. A frameshift mutation in prominin (mouse)-like 1 causes human retinal degeneration. Maw, M.A., Corbeil, D., Koch, J., Hellwig, A., Wilson-Wheeler, J.C., Bridges, R.J., Kumaramanickavel, G., John, S., Nancarrow, D., Röper, K., Weigmann, A., Huttner, W.B., Denton, M.J. Hum. Mol. Genet. (2000) [Pubmed]
  2. Expression of AC133, a novel hematopoietic precursor antigen, on acute myeloid leukemia cells. Horn, P.A., Tesch, H., Staib, P., Kube, D., Diehl, V., Voliotis, D. Blood (1999) [Pubmed]
  3. Prominin-1/CD133, a neural and hematopoietic stem cell marker, is expressed in adult human differentiated cells and certain types of kidney cancer. Florek, M., Haase, M., Marzesco, A.M., Freund, D., Ehninger, G., Huttner, W.B., Corbeil, D. Cell Tissue Res. (2005) [Pubmed]
  4. Biology and plasticity of CD133+ hematopoietic stem cells. Handgretinger, R., Gordon, P.R., Leimig, T., Chen, X., Buhring, H.J., Niethammer, D., Kuci, S. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  5. Endothelial progenitor cells in infantile hemangioma. Yu, Y., Flint, A.F., Mulliken, J.B., Wu, J.K., Bischoff, J. Blood (2004) [Pubmed]
  6. Stem cell marker CD133 affects clinical outcome in glioma patients. Zeppernick, F., Ahmadi, R., Campos, B., Dictus, C., Helmke, B.M., Becker, N., Lichter, P., Unterberg, A., Radlwimmer, B., Herold-Mende, C.C. Clin. Cancer Res. (2008) [Pubmed]
  7. Poor perinatal outcome associated with retained cerclage in patients with premature rupture of membranes. Ludmir, J., Bader, T., Chen, L., Lindenbaum, C., Wong, G. Obstetrics and gynecology. (1994) [Pubmed]
  8. Dietary habits, prepregnancy weight, and weight gain during pregnancy. Risk of pre term rupture of amniotic sac membranes. Gosselink, C.A., Ekwo, E.E., Woolson, R.F., Moawad, A., Long, C.R. Acta obstetricia et gynecologica Scandinavica. (1992) [Pubmed]
  9. Subtracting the Math: prominin-positive cerebellar stem cells in white matter. Kenney, A.M., Segal, R.A. Nat. Neurosci. (2005) [Pubmed]
  10. Human circulating AC133(+) stem cells restore dystrophin expression and ameliorate function in dystrophic skeletal muscle. Torrente, Y., Belicchi, M., Sampaolesi, M., Pisati, F., Meregalli, M., D'Antona, G., Tonlorenzi, R., Porretti, L., Gavina, M., Mamchaoui, K., Pellegrino, M.A., Furling, D., Mouly, V., Butler-Browne, G.S., Bottinelli, R., Cossu, G., Bresolin, N. J. Clin. Invest. (2004) [Pubmed]
  11. Selection based on CD133 and high aldehyde dehydrogenase activity isolates long-term reconstituting human hematopoietic stem cells. Hess, D.A., Wirthlin, L., Craft, T.P., Herrbrich, P.E., Hohm, S.A., Lahey, R., Eades, W.C., Creer, M.H., Nolta, J.A. Blood (2006) [Pubmed]
  12. Pentoxifylline in the treatment of radiation-induced fibrosis. Okunieff, P., Augustine, E., Hicks, J.E., Cornelison, T.L., Altemus, R.M., Naydich, B.G., Ding, I., Huser, A.K., Abraham, E.H., Smith, J.J., Coleman, N., Gerber, L.H. J. Clin. Oncol. (2004) [Pubmed]
  13. Prominin: a story of cholesterol, plasma membrane protrusions and human pathology. Corbeil, D., Röper, K., Fargeas, C.A., Joester, A., Huttner, W.B. Traffic (2001) [Pubmed]
  14. Management of preterm premature rupture of membranes. Veille, J.C. Clinics in perinatology. (1988) [Pubmed]
  15. Perinatal and maternal outcome following abruptio placentae. Witlin, A.G., Sibai, B.M. Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy. (2001) [Pubmed]
  16. AC133 antigen as a prognostic factor in acute leukemia. Lee, S.T., Jang, J.H., Min, Y.H., Hahn, J.S., Ko, Y.W. Leuk. Res. (2001) [Pubmed]
  17. Emergence of muscle and neural hematopoiesis in humans. Jay, K.E., Gallacher, L., Bhatia, M. Blood (2002) [Pubmed]
  18. Histone deacetylase inhibitor valproic acid enhances the cytokine-induced expansion of human hematopoietic stem cells. De Felice, L., Tatarelli, C., Mascolo, M.G., Gregorj, C., Agostini, F., Fiorini, R., Gelmetti, V., Pascale, S., Padula, F., Petrucci, M.T., Arcese, W., Nervi, C. Cancer Res. (2005) [Pubmed]
  19. AC133, a novel marker for human hematopoietic stem and progenitor cells. Yin, A.H., Miraglia, S., Zanjani, E.D., Almeida-Porada, G., Ogawa, M., Leary, A.G., Olweus, J., Kearney, J., Buck, D.W. Blood (1997) [Pubmed]
  20. Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. Frank, N.Y., Pendse, S.S., Lapchak, P.H., Margaryan, A., Shlain, D., Doeing, C., Sayegh, M.H., Frank, M.H. J. Biol. Chem. (2003) [Pubmed]
  21. Identification and characterization of a novel testosterone-regulated prominin-like gene in the rat ventral prostate. Zhang, Q., Haleem, R., Cai, X., Wang, Z. Endocrinology (2002) [Pubmed]
  22. The post-hemodialysis rebound: predicting and quantifying its effect on Kt/V. Tattersall, J.E., DeTakats, D., Chamney, P., Greenwood, R.N., Farrington, K. Kidney Int. (1996) [Pubmed]
  23. TGFBR3 loss and consequences in prostate cancer. Sharifi, N., Hurt, E.M., Kawasaki, B.T., Farrar, W.L. Prostate (2007) [Pubmed]
  24. Expression of stem cells markers in ocular hemangioblastoma associated with von Hippel-Lindau (VHL) disease. Chan, C.C., Chew, E.Y., Shen, D., Hackett, J., Zhuang, Z. Mol. Vis. (2005) [Pubmed]
  25. Intermediate filament nestin expressions in human cord blood monocytes (HCMNCs). Ha, Y., Lee, J.E., Kim, K.N., Cho, Y.E., Yoon, D.H. Acta neurochirurgica. (2003) [Pubmed]
  26. Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors. Peichev, M., Naiyer, A.J., Pereira, D., Zhu, Z., Lane, W.J., Williams, M., Oz, M.C., Hicklin, D.J., Witte, L., Moore, M.A., Rafii, S. Blood (2000) [Pubmed]
  27. Identification and clinical significance of circulating endothelial progenitor cells in human non-small cell lung cancer. Dome, B., Timar, J., Dobos, J., Meszaros, L., Raso, E., Paku, S., Kenessey, I., Ostoros, G., Magyar, M., Ladanyi, A., Bogos, K., Tovari, J. Cancer Res. (2006) [Pubmed]
  28. Endothelial progenitor cell culture and differentiation in vitro: a methodological comparison using human umbilical cord blood. Eggermann, J., Kliche, S., Jarmy, G., Hoffmann, K., Mayr-Beyrle, U., Debatin, K.M., Waltenberger, J., Beltinger, C. Cardiovasc. Res. (2003) [Pubmed]
  29. The human AC133 hematopoietic stem cell antigen is also expressed in epithelial cells and targeted to plasma membrane protrusions. Corbeil, D., Röper, K., Hellwig, A., Tavian, M., Miraglia, S., Watt, S.M., Simmons, P.J., Peault, B., Buck, D.W., Huttner, W.B. J. Biol. Chem. (2000) [Pubmed]
  30. Potential role of activated platelets in homing of human endothelial progenitor cells to subendothelial matrix. Lev, E.I., Estrov, Z., Aboulfatova, K., Harris, D., Granada, J.F., Alviar, C., Kleiman, N.S., Dong, J.F. Thromb. Haemost. (2006) [Pubmed]
  31. Feasibility and safety of G-CSF administration to induce bone marrow-derived cells mobilization in patients with end stage liver disease. Gaia, S., Smedile, A., Omedè, P., Olivero, A., Sanavio, F., Balzola, F., Ottobrelli, A., Abate, M.L., Marzano, A., Rizzetto, M., Tarella, C. J. Hepatol. (2006) [Pubmed]
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