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Gene Review

Foxq1  -  forkhead box Q1

Mus musculus

Synonyms: Forkhead box protein Q1, HFH-1, HFH-1l, HNF-3/forkhead-like protein 1, Hepatocyte nuclear factor 3 forkhead homolog 1, ...
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High impact information on Foxq1


Biological context of Foxq1

  • Hk1-sa mRNA is first expressed during meiosis and continues to be present in postmeiotic germ cells, while the more abundant Hk1-sb mRNA is detected only in postmeiotic germ cells [4].

Anatomical context of Foxq1

  • Expression of additional medulla-specific genes down-regulated upon overexpression of Hoxc13 requires functional Foxq1 as their expression is ablated in hair follicles of satin mice [2].

Physical interactions of Foxq1

  • HFH-1 does not disrupt serum response factor binding to an adjacent CArG box within the telokin promoter, implying that HFH-1 must compete with other unidentified trans-activators to mediate repression [3].


  1. Pleiotropic skeletal and ocular phenotypes of the mouse mutation congenital hydrocephalus (ch/Mf1) arise from a winged helix/forkhead transcriptionfactor gene. Hong, H.K., Lass, J.H., Chakravarti, A. Hum. Mol. Genet. (1999) [Pubmed]
  2. Evidence That the Satin Hair Mutant Gene Foxq1 Is among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 during Hair Follicle Differentiation. Potter, C.S., Peterson, R.L., Barth, J.L., Pruett, N.D., Jacobs, D.F., Kern, M.J., Argraves, W.S., Sundberg, J.P., Awgulewitsch, A. J. Biol. Chem. (2006) [Pubmed]
  3. Hepatocyte nuclear factor-3 homologue 1 (HFH-1) represses transcription of smooth muscle-specific genes. Hoggatt, A.M., Kriegel, A.M., Smith, A.F., Herring, B.P. J. Biol. Chem. (2000) [Pubmed]
  4. Unique hexokinase messenger ribonucleic acids lacking the porin-binding domain are developmentally expressed in mouse spermatogenic cells. Mori, C., Welch, J.E., Fulcher, K.D., O'Brien, D.A., Eddy, E.M. Biol. Reprod. (1993) [Pubmed]
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