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Gene Review

FOXQ1  -  forkhead box Q1

Homo sapiens

Synonyms: Forkhead box protein Q1, HFH-1, HFH1, HNF-3/forkhead-like protein 1, Hepatocyte nuclear factor 3 forkhead homolog 1
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Disease relevance of FOXQ1


High impact information on FOXQ1

  • In this report we present studies on the DNA binding properties of winged-helix HNF-3/fkh homologues 1 (HFH-1) and 2 (HFH-2) which recognize a shared DNA binding site with different affinities [2].
  • Furthermore, the binding affinities of HFH-1 and HFH-2 toward DNA binding sites with base-pair reversion in the AAAATAAC sequence was also investigated [2].
  • Different patterns of response from HFH-1 and HFH-2 to both prebent and base-pair reverted binding sites was observed [2].
  • HFH-1 and HFH-2 were shown to recognize DNA sites prebent at many nucleotide positions on both strands of the DNA sequence [2].
  • Structure comparison of two conserved HNF-3/fkh proteins HFH-1 and genesis indicates the existence of folding differences in their complexes with a DNA binding sequence [3].

Biological context of FOXQ1

  • The FOXQ1 gene is located on chromosome 6p23-25 [1].
  • We show that Foxq1 is expressed during embryogenesis and exhibits a tissue-restricted expression pattern in adult tissues [4].

Anatomical context of FOXQ1


Other interactions of FOXQ1

  • Three forkhead genes (FOXF1 and FOXQ1 from within the critical region, and FOXC1 proximal to this region) were evaluated as potential candidate disease genes for this disorder [5].


  1. Isolation and characterization of the human forkhead gene FOXQ1. Bieller, A., Pasche, B., Frank, S., Gläser, B., Kunz, J., Witt, K., Zoll, B. DNA Cell Biol. (2001) [Pubmed]
  2. Different DNA contact schemes are used by two winged helix proteins to recognize a DNA binding sequence. Bravieri, R., Shiyanova, T., Chen, T.H., Overdier, D., Liao, X. Nucleic Acids Res. (1997) [Pubmed]
  3. Structure comparison of two conserved HNF-3/fkh proteins HFH-1 and genesis indicates the existence of folding differences in their complexes with a DNA binding sequence. Sheng, W., Rance, M., Liao, X. Biochemistry (2002) [Pubmed]
  4. The winged helix/forkhead transcription factor Foxq1 regulates differentiation of hair in satin mice. Hong, H.K., Noveroske, J.K., Headon, D.J., Liu, T., Sy, M.S., Justice, M.J., Chakravarti, A. Genesis (2001) [Pubmed]
  5. Subtelomeric deletions of chromosome 6p: molecular and cytogenetic characterization of three new cases with phenotypic overlap with Ritscher-Schinzel (3C) syndrome. Descipio, C., Schneider, L., Young, T.L., Wasserman, N., Yaeger, D., Lu, F., Wheeler, P.G., Williams, M.S., Bason, L., Jukofsky, L., Menon, A., Geschwindt, R., Chudley, A.E., Saraiva, J., Schinzel, A.A., Guichet, A., Dobyns, W.E., Toutain, A., Spinner, N.B., Krantz, I.D. Am. J. Med. Genet. A (2005) [Pubmed]
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