Disease relevance of FOXQ1

• Additionally, overexpression of human FOXQ1 was shown in colorectal adenocarcinoma and lung carcinoma cell lines [1].

High impact information on FOXQ1

• In this report we present studies on the DNA binding properties of winged-helix HNF-3/fkh homologues 1 (HFH-1) and 2 (HFH-2) which recognize a shared DNA binding site with different affinities [2].
• Furthermore, the binding affinities of HFH-1 and HFH-2 toward DNA binding sites with base-pair reversion in the AAAATAAC sequence was also investigated [2].
• Different patterns of response from HFH-1 and HFH-2 to both prebent and base-pair reverted binding sites was observed [2].
• HFH-1 and HFH-2 were shown to recognize DNA sites prebent at many nucleotide positions on both strands of the DNA sequence [2].
• Structure comparison of two conserved HNF-3/fkh proteins HFH-1 and genesis indicates the existence of folding differences in their complexes with a DNA binding sequence [3].

Biological context of FOXQ1

• The FOXQ1 gene is located on chromosome 6p23-25 [1].
• We show that Foxq1 is expressed during embryogenesis and exhibits a tissue-restricted expression pattern in adult tissues [4].

Anatomical context of FOXQ1

• The 2.7-kb transcript of the human FOXQ1 gene is expressed predominantly in the stomach, trachea, bladder and salivary gland [1].

Other interactions of FOXQ1

• Three forkhead genes (FOXF1 and FOXQ1 from within the critical region, and FOXC1 proximal to this region) were evaluated as potential candidate disease genes for this disorder [5].

References