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Gene Review:

Hsd3b3 - hydroxy-delta-5-steroid dehydrogenase, 3...

Mus musculus

Synonyms: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type III, 3-beta-HSD III, 9030618K22Rik, AI790201

Clarke, T.R. et al., Park, C.H. et al., Clarke, T.R. et al.

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High impact information on Hsd3b3

Mouse 3 beta HSD IV is functionally and structurally most closely related to rat 3 beta HSD III, an isoform expressed predominantly in male rat liver [1].
Km values of 3 beta HSD III were greater for all substrates, with the greatest increase observed for pregnenolone, which was over 10-fold greater [2].
In the current study, we present data which demonstrate that transiently expressed 3 beta HSD I and 3 beta HSD III proteins can catalyze the conversion of the delta 5-steroids, pregnenolone and dehydroepiandrosterone, to their respective delta 4-3-ketosteroids, progesterone and androstenedione [2].

Biological context of Hsd3b3

3 beta HSD I, which in the adult mouse is expressed only in the gonads and adrenal glands, is the major isoform expressed in both male and female livers during fetal development until the first postnatal (pn) day after which time 3 beta HSD III becomes the major isoform [3].

Other interactions of Hsd3b3

Previously it was shown that the liver of the adult mouse expresses 3 beta HSD II, III and V, with 3 beta HSD III being the major isoform [3].

References

A novel mouse kidney 3 beta-hydroxysteroid dehydrogenase complementary DNA encodes a 3-ketosteroid reductase instead of a 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase. Clarke, T.R., Bain, P.A., Greco, T.L., Payne, A.H. Mol. Endocrinol. (1993) [Pubmed]
Enzyme characteristics of two distinct forms of mouse 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase complementary deoxyribonucleic acids expressed in COS-1 cells. Clarke, T.R., Bain, P.A., Sha, L., Payne, A.H. Endocrinology (1993) [Pubmed]
Expression of multiple forms of 3 beta-hydroxysteroid dehydrogenase in the mouse liver during fetal and postnatal development. Park, C.H., Abbaszade, I.G., Payne, A.H. Mol. Cell. Endocrinol. (1996) [Pubmed]

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HSD3B1	Homo sapiens
HSD3B1	Macaca mulatta
Hsd3b2	Mus musculus
Hsd3b6	Mus musculus
HSD3B1	Pan troglodytes

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