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Gene Review

Olfr67  -  olfactory receptor 67

Mus musculus

Synonyms: 3'[b]1, 3'beta1, GA_x6K02T2PBJ9-6515150-6514170, MOR31-1
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Disease relevance of Olfr67


Psychiatry related information on Olfr67


High impact information on Olfr67


Chemical compound and disease context of Olfr67

  • Glycogen synthase kinase 3beta inhibitor Chir025 reduces neuronal death resulting from oxygen-glucose deprivation, glutamate excitotoxicity, and cerebral ischemia [11].
  • Glycogen synthase kinase 3beta together with 14-3-3 protein regulates diabetic cardiomyopathy: effect of losartan and tempol [12].
  • Treatment with the anti-glucocorticoid hormones dehydroepiandrosterone or 3 beta, 17 beta-androstenediol, during the period of adrenal hyperplasia, maintains Th1 dominance and is protective [13].
  • Previously we have formulated a new cationic emulsion, composed of 3beta [N-(N',N'-dimethylaminoethane) carbamoyl] cholesterol and dioleoylphosphatidyl ethanolamine, castor oil and Tween 80, and it efficiently delivered plasmid DNA into various cancer cells with low toxicity [14].
  • Animals in this late progressive phase of the disease (day 60) were treated with two injections (day 60 and day 90) of 0.1 or 1.0 mg of heat-killed Mycobacterium vaccae, or with 3beta, 17beta-androstenediol (AED; 25 microg subcutaneously three times/week), or with both therapies [15].

Biological context of Olfr67


Anatomical context of Olfr67


Associations of Olfr67 with chemical compounds

  • Conversely, lithium chloride, which inhibits glycogen synthase kinase 3beta, and Wnt3A-conditioned medium up-regulated early cardiac markers and the proportion of differentiated cells [26].
  • Activating mutations in the region of the beta-catenin gene corresponding to the NH2-terminal phosphorylation sites of glycogen synthetase kinase 3beta have been causally implicated in carcinogenesis [27].
  • A positive feedback loop between glycogen synthase kinase 3beta and protein phosphatase 1 after stimulation of NR2B NMDA receptors in forebrain neurons [28].
  • Specifically, we show that activation of PPARgamma by exposure of Swiss mouse fibroblasts to troglitazone stimulates the degradation of beta-catenin, which depends on glycogen synthase kinase (GSK) 3beta activity [29].
  • The enzyme 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase (3 beta HSD) is essential for the biosynthesis of all steroid hormones [20].

Regulatory relationships of Olfr67


Other interactions of Olfr67

  • Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcription [31].
  • The four 3 beta HSD structural genes (Hsd3b) are closely linked within a segment of chromosome 3 that is conserved on human chromosome 1 [32].
  • Kinases downstream of MAPK such as p90rsk and glycogen synthase kinase 3beta were only marginally affected [33].
  • Previously it was shown that the liver of the adult mouse expresses 3 beta HSD II, III and V, with 3 beta HSD III being the major isoform [34].
  • The expression of transacting factors hepatocyte nuclear factors 3 alpha and 3 beta (HNF-3 alpha and HNF-3 beta) were also analyzed, and a transient increase in the expression of HNF-3 beta but not HNF-3 alpha was detected [35].

Analytical, diagnostic and therapeutic context of Olfr67

  • Recent findings implicating the GH-regulated transcription factor STAT5b (signal transducer and activator of transcription 5b), hepatocyte nuclear factors 3beta, 4alpha and 6, and sex differences in DNA methylation and chromatin structure in the sex-dependent actions of GH are reviewed, and current mechanistic models are evaluated [36].
  • Three distinct immunoreactive species [molecular masses, 47, 44, and 42 kilodaltons (kDa)] are detectable by Western immunoblot analysis using a 3 beta HSD antiserum [37].
  • Oligonucleotides with unique sequences but encoding homologous regions of the mouse type I, II, and III 3 beta HSD cDNAs were used for Northern blot analyses [37].
  • Two weeks after sham-operation or castration, no castration effect was seen in adrenal 3 beta HSD activity, but the sex difference had been eliminated in C57BL/6J animals [38].
  • The influence of a new eburnamenine derivative RU 24722 [(3 beta, 14 alpha, 16 alpha)-(+/-)-14,15-dihydro-20,21-dinoreburnamenin -14-ol] on post-ischemic EEG recovery was studied in N2O anesthetized rats subjected to 1 min of global-compression cerebral ischemia [39].


  1. Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells. Ougolkov, A.V., Fernandez-Zapico, M.E., Savoy, D.N., Urrutia, R.A., Billadeau, D.D. Cancer Res. (2005) [Pubmed]
  2. Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart. Michael, A., Haq, S., Chen, X., Hsich, E., Cui, L., Walters, B., Shao, Z., Bhattacharya, K., Kilter, H., Huggins, G., Andreucci, M., Periasamy, M., Solomon, R.N., Liao, R., Patten, R., Molkentin, J.D., Force, T. J. Biol. Chem. (2004) [Pubmed]
  3. Inactivation of integrin-linked kinase induces aberrant tau phosphorylation via sustained activation of glycogen synthase kinase 3beta in N1E-115 neuroblastoma cells. Ishii, T., Furuoka, H., Muroi, Y., Nishimura, M. J. Biol. Chem. (2003) [Pubmed]
  4. Mechanisms of inhibition of nuclear hormone receptor-dependent hepatitis B virus replication by hepatocyte nuclear factor 3beta. Tang, H., McLachlan, A. J. Virol. (2002) [Pubmed]
  5. Activation of p53-dependent apoptosis by acute ablation of glycogen synthase kinase-3beta in colorectal cancer cells. Ghosh, J.C., Altieri, D.C. Clin. Cancer Res. (2005) [Pubmed]
  6. Lithium regulates glycogen synthase kinase-3beta in human peripheral blood mononuclear cells: implication in the treatment of bipolar disorder. Li, X., Friedman, A.B., Zhu, W., Wang, L., Boswell, S., May, R.S., Davis, L.L., Jope, R.S. Biol. Psychiatry (2007) [Pubmed]
  7. A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex. Reiser, J.B., Grégoire, C., Darnault, C., Mosser, T., Guimezanes, A., Schmitt-Verhulst, A.M., Fontecilla-Camps, J.C., Mazza, G., Malissen, B., Housset, D. Immunity (2002) [Pubmed]
  8. Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis. Murray, N.R., Davidson, L.A., Chapkin, R.S., Clay Gustafson, W., Schattenberg, D.G., Fields, A.P. J. Cell Biol. (1999) [Pubmed]
  9. Sequential phosphorylation of CCAAT enhancer-binding protein beta by MAPK and glycogen synthase kinase 3beta is required for adipogenesis. Tang, Q.Q., Grønborg, M., Huang, H., Kim, J.W., Otto, T.C., Pandey, A., Lane, M.D. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  10. Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Clément-Lacroix, P., Ai, M., Morvan, F., Roman-Roman, S., Vayssière, B., Belleville, C., Estrera, K., Warman, M.L., Baron, R., Rawadi, G. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  11. Glycogen synthase kinase 3beta inhibitor Chir025 reduces neuronal death resulting from oxygen-glucose deprivation, glutamate excitotoxicity, and cerebral ischemia. Kelly, S., Zhao, H., Hua Sun, G., Cheng, D., Qiao, Y., Luo, J., Martin, K., Steinberg, G.K., Harrison, S.D., Yenari, M.A. Exp. Neurol. (2004) [Pubmed]
  12. Glycogen synthase kinase 3beta together with 14-3-3 protein regulates diabetic cardiomyopathy: effect of losartan and tempol. Gurusamy, N., Watanabe, K., Ma, M., Prakash, P., Hirabayashi, K., Zhang, S., Muslin, A.J., Kodama, M., Aizawa, Y. FEBS Lett. (2006) [Pubmed]
  13. Emergent immunoregulatory properties of combined glucocorticoid and anti-glucocorticoid steroids in a model of tuberculosis. Hernandez-Pando, R., de la Luz Streber, M., Orozco, H., Arriaga, K., Pavon, L., Marti, O., Lightman, S.L., Rook, G.A. QJM : monthly journal of the Association of Physicians. (1998) [Pubmed]
  14. The use of chitosan as a condensing agent to enhance emulsion-mediated gene transfer. Lee, M.K., Chun, S.K., Choi, W.J., Kim, J.K., Choi, S.H., Kim, A., Oungbho, K., Park, J.S., Ahn, W.S., Kim, C.K. Biomaterials (2005) [Pubmed]
  15. Interactions between hormone-mediated and vaccine-mediated immunotherapy for pulmonary tuberculosis in BALB/c mice. Hernandez-Pando, R., Pavon, L., Orozco, E.H., Rangel, J., Rook, G.A. Immunology (2000) [Pubmed]
  16. A functional hot spot for antigen recognition in a superagonist TCR/MHC complex. Degano, M., Garcia, K.C., Apostolopoulos, V., Rudolph, M.G., Teyton, L., Wilson, I.A. Immunity (2000) [Pubmed]
  17. Upstream G gamma-globin and downstream beta-globin sequences required for stage-specific expression in transgenic mice. Trudel, M., Magram, J., Bruckner, L., Costantini, F. Mol. Cell. Biol. (1987) [Pubmed]
  18. Genetic complexity and expression of human class II histocompatibility antigens. Korman, A.J., Boss, J.M., Spies, T., Sorrentino, R., Okada, K., Strominger, J.L. Immunol. Rev. (1985) [Pubmed]
  19. Novel anti-inflammatory role for glycogen synthase kinase-3beta in the inhibition of tumor necrosis factor-alpha- and interleukin-1beta-induced inflammatory gene expression. Vines, A., Cahoon, S., Goldberg, I., Saxena, U., Pillarisetti, S. J. Biol. Chem. (2006) [Pubmed]
  20. A novel mouse kidney 3 beta-hydroxysteroid dehydrogenase complementary DNA encodes a 3-ketosteroid reductase instead of a 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase. Clarke, T.R., Bain, P.A., Greco, T.L., Payne, A.H. Mol. Endocrinol. (1993) [Pubmed]
  21. Multiple forms of mouse 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase and differential expression in gonads, adrenal glands, liver, and kidneys of both sexes. Bain, P.A., Yoo, M., Clarke, T., Hammond, S.H., Payne, A.H. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  22. Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T cell receptor beta repertoire and small clone size. Matsuda, J.L., Gapin, L., Fazilleau, N., Warren, K., Naidenko, O.V., Kronenberg, M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  23. Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues. Ye, H., Kelly, T.F., Samadani, U., Lim, L., Rubio, S., Overdier, D.G., Roebuck, K.A., Costa, R.H. Mol. Cell. Biol. (1997) [Pubmed]
  24. Augmentation of therapeutic angiogenesis using genetically modified human endothelial progenitor cells with altered glycogen synthase kinase-3beta activity. Choi, J.H., Hur, J., Yoon, C.H., Kim, J.H., Lee, C.S., Youn, S.W., Oh, I.Y., Skurk, C., Murohara, T., Park, Y.B., Walsh, K., Kim, H.S. J. Biol. Chem. (2004) [Pubmed]
  25. Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice. Spittaels, K., Van den Haute, C., Van Dorpe, J., Geerts, H., Mercken, M., Bruynseels, K., Lasrado, R., Vandezande, K., Laenen, I., Boon, T., Van Lint, J., Vandenheede, J., Moechars, D., Loos, R., Van Leuven, F. J. Biol. Chem. (2000) [Pubmed]
  26. A Wnt- and beta -catenin-dependent pathway for mammalian cardiac myogenesis. Nakamura, T., Sano, M., Songyang, Z., Schneider, M.D. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  27. Beta-catenin mutations are frequent in hepatocellular carcinomas but absent in adenomas induced by diethylnitrosamine in B6C3F1 mice. Ogawa, K., Yamada, Y., Kishibe, K., Ishizaki, K., Tokusashi, Y. Cancer Res. (1999) [Pubmed]
  28. A positive feedback loop between glycogen synthase kinase 3beta and protein phosphatase 1 after stimulation of NR2B NMDA receptors in forebrain neurons. Szatmari, E., Habas, A., Yang, P., Zheng, J.J., Hagg, T., Hetman, M. J. Biol. Chem. (2005) [Pubmed]
  29. Regulating the balance between peroxisome proliferator-activated receptor gamma and beta-catenin signaling during adipogenesis. A glycogen synthase kinase 3beta phosphorylation-defective mutant of beta-catenin inhibits expression of a subset of adipogenic genes. Liu, J., Farmer, S.R. J. Biol. Chem. (2004) [Pubmed]
  30. Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase. Liu, S., Yu, S., Hasegawa, Y., Lapushin, R., Xu, H.J., Woodgett, J.R., Mills, G.B., Fang, X. J. Biol. Chem. (2004) [Pubmed]
  31. Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcription. Steinbrecher, K.A., Wilson, W., Cogswell, P.C., Baldwin, A.S. Mol. Cell. Biol. (2005) [Pubmed]
  32. The genes encoding gonadal and nongonadal forms of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase are closely linked on mouse chromosome 3. Bain, P.A., Meisler, M.H., Taylor, B.A., Payne, A.H. Genomics (1993) [Pubmed]
  33. Activation of mitogen-activated protein kinase cascade and phosphorylation of cytoskeletal proteins after neurone-specific activation of p21ras. I. Mitogen-activated protein kinase cascade. Holzer, M., Gärtner, U., Klinz, F.J., Narz, F., Heumann, R., Arendt, T. Neuroscience (2001) [Pubmed]
  34. Expression of multiple forms of 3 beta-hydroxysteroid dehydrogenase in the mouse liver during fetal and postnatal development. Park, C.H., Abbaszade, I.G., Payne, A.H. Mol. Cell. Endocrinol. (1996) [Pubmed]
  35. Interferon-gamma regulation of Clara cell gene expression: in vivo and in vitro. Magdaleno, S.M., Wang, G., Jackson, K.J., Ray, M.K., Welty, S., Costa, R.H., DeMayo, F.J. Am. J. Physiol. (1997) [Pubmed]
  36. Growth hormone regulation of sex-dependent liver gene expression. Waxman, D.J., O'connor, C. Mol. Endocrinol. (2006) [Pubmed]
  37. Multiple isoforms of 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase in mouse tissues: male-specific isoforms are expressed in the gonads and liver. Keeney, D.S., Naville, D., Milewich, L., Bartke, A., Mason, J.I. Endocrinology (1993) [Pubmed]
  38. Gonadal steroids modulate adrenal fasciculata 3 beta-hydroxysteroid dehydrogenase-isomerase activity in mice. Perry, J.E., Stalvey, J.R. Biol. Reprod. (1992) [Pubmed]
  39. Effects of the new eburnamenine derivative RU 24722 on EEG recovery and cerebral energy metabolism after complete ischemia. Barzaghi, F., Dragonetti, M., Formento, M.L., Boissier, J.R. Arzneimittel-Forschung. (1985) [Pubmed]
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