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Gene Review

Hsd3b6  -  hydroxy-delta-5-steroid dehydrogenase, 3...

Mus musculus

Synonyms: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 6, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type VI, 3-beta-HSD VI, 3beta-HSD VI, D19210
 
 
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High impact information on Hsd3b6

  • Site-specific mutations in each of the binding sites eliminated enhancer activity indicating that AP-2 gamma and Dlx 3, together with an additional transcription factor(s) that are conserved between humans and mice, are required for trophoblast-specific expression of 3 beta-HSD VI [1].
  • The murine ortholog, 3 beta-HSD VI, is the only isoform expressed in giant trophoblast cells during the first half of mouse pregnancy [1].
  • Transfection studies in placental and nonplacental cells identified a novel 66-bp trophoblast-specific enhancer element located between -2896 and -2831 of the 3 beta-HSD VI promoter [1].
  • Isolation of a new mouse 3beta-hydroxysteroid dehydrogenase isoform, 3beta-HSD VI, expressed during early pregnancy [2].
  • 3beta-HSD VI is the earliest isoform to be expressed during embryogenesis in cells of embryonic origin at 7 and 9.5 days postcoitum (pc), and is the major isoform expressed in uterine tissue at the time of implantation (4.5 days pc) and continues to be expressed in uterine tissue at 6.5, 7.5, and 9.5 days pc [2].
 

Anatomical context of Hsd3b6

 

Associations of Hsd3b6 with chemical compounds

References

 
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