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Gene Review:

Incenp - inner centromere protein

Mus musculus

Synonyms: 2700067E22Rik, AU019509, C130081E20, C77457, Inner centromere protein

Tang, C.J. et al., Fowler, K.J. et al., Earnshaw, W.C. et al., Cutts, S.M. et al., Uren, A.G. et al.

Fowler, Saffery, Kile, Irvine, Hudson, Trowell, Choo,

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High impact information on Incenp

Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice [1].
Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype [2].
We propose that INCENP recruits Aurora-C (or some other factor(s) recruit INCENP and Aurora-C) to meiotic chromosomes, while Aurora-C may either work alone or cooperate with Aurora-B to regulate chromosome segregation during male meiosis [3].
Furthermore, immunoprecipitation analyses revealed that INCENP associated with Aurora-C in the male testis [3].
Using a mouse Incenp genomic DNA and a mouse Cenpe cDNA to analyze recombinant inbred mouse sets, as well as interspecific backcross panels, we have mapped these genes to the proximal regions of mouse Chromosomes 19 and 6, respectively [4].

Biological context of Incenp

Genetic mapping of mouse centromere protein (Incenp and Cenpe) genes [4].
Several lines of evidence suggest that the INCENP polypeptides may be involved in the regulation of sister chromatid separation at the metaphase-anaphase transition [5].
The INCENP antigens undergo dramatic movements from the chromosomes to the central spindle during mitosis [5].

References

Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice. Cutts, S.M., Fowler, K.J., Kile, B.T., Hii, L.L., O'Dowd, R.A., Hudson, D.F., Saffery, R., Kalitsis, P., Earle, E., Choo, K.H. Hum. Mol. Genet. (1999) [Pubmed]
Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. Uren, A.G., Wong, L., Pakusch, M., Fowler, K.J., Burrows, F.J., Vaux, D.L., Choo, K.H. Curr. Biol. (2000) [Pubmed]
Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis. Tang, C.J., Lin, C.Y., Tang, T.K. Dev. Biol. (2006) [Pubmed]
Genetic mapping of mouse centromere protein (Incenp and Cenpe) genes. Fowler, K.J., Saffery, R., Kile, B.T., Irvine, D.V., Hudson, D.F., Trowell, H.E., Choo, K.H. Cytogenet. Cell Genet. (1998) [Pubmed]
Proteins of the inner and outer centromere of mitotic chromosomes. Earnshaw, W.C., Cooke, C.A. Genome (1989) [Pubmed]

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