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Gene Review

Birc5  -  baculoviral IAP repeat-containing 5

Mus musculus

Synonyms: AAC-11, Api4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, Baculoviral IAP repeat-containing protein 5, ...
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Disease relevance of Birc5


High impact information on Birc5


Chemical compound and disease context of Birc5

  • Expression of a phosphorylation-defective survivin mutant (Thr(34)-->Ala) triggered apoptosis in several human melanoma cell lines and enhanced cell death induced by the chemotherapeutic drug cisplatin in vitro [8].
  • Plasmid constructs expressing survivin antisense and DN mutant replacing the cysteine residue at amino acid 84 with alanine (Cys84Ala) were prepared and introduced into BCG-823 and MKN-45 gastric cancer cells to establish stable transfectants [9].
  • We decided to evaluate the effects of a ribozyme-based strategy for survivin inhibition in androgen-independent human prostate cancer cells [10].
  • METHODS: A semiautomatic 3-dimensional algorithm was used to delineate the LV myocardial wall on static PET images depicting myocardial glucose metabolism ((18)F-FDG PET) for 20 mice: 10 wild-type and 10 genetically modified littermates designed to develop a dilative cardiomyopathy phenotype (cardiomyocyte-specific knockout of survivin) [11].
  • Our study, for the first time, demonstrated that 1) resveratrol imparts strong chemopreventive effects against UVB exposure-mediated skin carcinogenesis (relevant to human skin cancers), and 2) the chemopreventive effects of resveratrol may, at least in part, be mediated via modulations in Survivin and other associated events [12].

Biological context of Birc5


Anatomical context of Birc5


Associations of Birc5 with chemical compounds


Regulatory relationships of Birc5


Other interactions of Birc5


Analytical, diagnostic and therapeutic context of Birc5


  1. Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation. Kobayashi, K., Hatano, M., Otaki, M., Ogasawara, T., Tokuhisa, T. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer. Cao, C., Mu, Y., Hallahan, D.E., Lu, B. Oncogene (2004) [Pubmed]
  3. Survivin inhibits anti-growth effect of p53 activated by aurora B. Jung, J.E., Kim, T.K., Lee, J.S., Oh, S.Y., Kwak, S., Jin, X., Sohn, J.Y., Song, M.K., Sohn, Y.W., Lee, S.Y., Pian, X., Lee, J.B., Chung, Y.G., Choi, Y.K., You, S., Kim, H. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  4. Lentivirus-mediated gene therapy by suppressing survivin in BALB/c nude mice bearing oral squamous cell carcinoma. Jiang, G., Li, J., Zeng, Z., Xian, L. Cancer Biol. Ther. (2006) [Pubmed]
  5. Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes. Mori, F., Piro, F.R., Della Rocca, C., Mesiti, G., Giampaoli, S., Silvestre, G., Lazzaro, D. Histol. Histopathol. (2007) [Pubmed]
  6. Inhibitor of apoptosis protein survivin regulates vascular injury. Blanc-Brude, O.P., Yu, J., Simosa, H., Conte, M.S., Sessa, W.C., Altieri, D.C. Nat. Med. (2002) [Pubmed]
  7. Control of apoptosis and mitotic spindle checkpoint by survivin. Li, F., Ambrosini, G., Chu, E.Y., Plescia, J., Tognin, S., Marchisio, P.C., Altieri, D.C. Nature (1998) [Pubmed]
  8. Inhibition of melanoma tumor growth in vivo by survivin targeting. Grossman, D., Kim, P.J., Schechner, J.S., Altieri, D.C. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  9. Suppression of survivin expression inhibits in vivo tumorigenicity and angiogenesis in gastric cancer. Tu, S.P., Jiang, X.H., Lin, M.C., Cui, J.T., Yang, Y., Lum, C.T., Zou, B., Zhu, Y.B., Jiang, S.H., Wong, W.M., Chan, A.O., Yuen, M.F., Lam, S.K., Kung, H.F., Wong, B.C. Cancer Res. (2003) [Pubmed]
  10. Ribozyme-mediated inhibition of survivin expression increases spontaneous and drug-induced apoptosis and decreases the tumorigenic potential of human prostate cancer cells. Pennati, M., Binda, M., Colella, G., Zoppe', M., Folini, M., Vignati, S., Valentini, A., Citti, L., De Cesare, M., Pratesi, G., Giacca, M., Daidone, M.G., Zaffaroni, N. Oncogene (2004) [Pubmed]
  11. Monitoring left ventricular dilation in mice with PET. Stegger, L., Schäfers, K.P., Flögel, U., Livieratos, L., Hermann, S., Jacoby, C., Keul, P., Conway, E.M., Schober, O., Schrader, J., Levkau, B., Schäfers, M. J. Nucl. Med. (2005) [Pubmed]
  12. Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease? Aziz, M.H., Reagan-Shaw, S., Wu, J., Longley, B.J., Ahmad, N. FASEB J. (2005) [Pubmed]
  13. Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. Song, J., So, T., Cheng, M., Tang, X., Croft, M. Immunity (2005) [Pubmed]
  14. Survivin regulates hematopoietic progenitor cell proliferation through p21WAF1/Cip1-dependent and -independent pathways. Fukuda, S., Mantel, C.R., Pelus, L.M. Blood (2004) [Pubmed]
  15. Inhibition of apoptosis by survivin improves transplantation of pancreatic islets for treatment of diabetes in mice. Dohi, T., Salz, W., Costa, M., Ariyan, C., Basadonna, G.P., Altieri, D.C. EMBO Rep. (2006) [Pubmed]
  16. Survivin contributes to the anti-apoptotic activities of transforming growth factor alpha in mouse blastocysts through phosphatidylinositol 3'-kinase pathway. Kawamura, K., Fukuda, J., Shimizu, Y., Kodama, H., Tanaka, T. Biol. Reprod. (2005) [Pubmed]
  17. Tetra-O-methyl nordihydroguaiaretic acid induces growth arrest and cellular apoptosis by inhibiting Cdc2 and survivin expression. Chang, C.C., Heller, J.D., Kuo, J., Huang, R.C. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  18. Survivin interacts with Smac/DIABLO in ovarian carcinoma cells but is redundant in Smac-mediated apoptosis. McNeish, I.A., Lopes, R., Bell, S.J., McKay, T.R., Fernandez, M., Lockley, M., Wheatley, S.P., Lemoine, N.R. Exp. Cell Res. (2005) [Pubmed]
  19. Antitumor effects of a novel phenylbutyrate-based histone deacetylase inhibitor, (S)-HDAC-42, in prostate cancer. Kulp, S.K., Chen, C.S., Wang, D.S., Chen, C.Y., Chen, C.S. Clin. Cancer Res. (2006) [Pubmed]
  20. Survivin expression in ovarian cancer and its correlation with clinico-pathological, surgical and apoptosis-related parameters. Ferrandina, G., Legge, F., Martinelli, E., Ranelletti, F.O., Zannoni, G.F., Lauriola, L., Gessi, M., Gallotta, V., Scambia, G. Br. J. Cancer (2005) [Pubmed]
  21. Expression of survivin during liver regeneration. Deguchi, M., Shiraki, K., Inoue, H., Okano, H., Ito, T., Yamanaka, T., Sugimoto, K., Sakai, T., Ohmori, S., Murata, K., Furusaka, A., Hisatomi, H., Nakano, T. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  22. Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death. Okada, H., Bakal, C., Shahinian, A., Elia, A., Wakeham, A., Suh, W.K., Duncan, G.S., Ciofani, M., Rottapel, R., Zúñiga-Pflücker, J.C., Mak, T.W. J. Exp. Med. (2004) [Pubmed]
  23. Differential roles for the coactivators CBP and p300 on TCF/beta-catenin-mediated survivin gene expression. Ma, H., Nguyen, C., Lee, K.S., Kahn, M. Oncogene (2005) [Pubmed]
  24. Procaspase 3 expression in ovarian carcinoma cells increases survivin transcription which can be countered with a dominant-negative mutant, survivin T34A; a combination gene therapy strategy. McKay, T.R., Bell, S., Tenev, T., Stoll, V., Lopes, R., Lemoine, N.R., McNeish, I.A. Oncogene (2003) [Pubmed]
  25. Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways. Conway, E.M., Pollefeyt, S., Steiner-Mosonyi, M., Luo, W., Devriese, A., Lupu, F., Bono, F., Leducq, N., Dol, F., Schaeffer, P., Collen, D., Herbert, J.M. Gastroenterology (2002) [Pubmed]
  26. Suppression of tumor growth using antisense oligonucleotide against survivin in an orthotopic transplant model of human hepatocellular carcinoma in nude mice. Sun, Y., Lin, R., Dai, J., Jin, D., Wang, S.Q. Oligonucleotides (2006) [Pubmed]
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