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Gene Review: 

Inpp1  -  inositol polyphosphate-1-phosphatase

Mus musculus

Synonyms: 2300002C06Rik, AV137389, IPP, IPPase, Inositol polyphosphate 1-phosphatase
 
 
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High impact information on Inpp1

  • Inositol polyphosphate 1-phosphatase (IPP) is an enzyme essential for the hydrolysis of the 1-phosphate from either Ins(1,4)P2 or Ins(1,3,4)P3 [1].
  • Utilizing the Jackson Lab backcross DNA panel map service, we mapped Inpp1 to chromosome 1, 1.06 cM proximal to Ctla4 [2].
  • We isolated a 1623-bp full-length Inpp1 cDNA from a mouse brain cDNA library using this amplified cDNA fragment as probe [2].
  • Amino acid sequences of mouse, human, and bovine inositol polyphosphate 1-phosphatase are highly conserved [2].
  • The two more virulent B. pseudomallei strains exhibited significantly different LD50, 3.5 x 10(2) (IPP 6068 VIR) versus 2.1 x 10(5) CFU/mouse (40/97), and protease activities (A405 = 0.046 and 0.79, respectively) [3].

References

  1. Synaptic defects and compensatory regulation of inositol metabolism in inositol polyphosphate 1-phosphatase mutants. Acharya, J.K., Labarca, P., Delgado, R., Jalink, K., Zuker, C.S. Neuron (1998) [Pubmed]
  2. Identification and chromosomal mapping of the mouse inositol polyphosphate 1-phosphatase gene. Okabe, I., Nussbaum, R.L. Genomics (1995) [Pubmed]
  3. Protease production by Burkholderia pseudomallei and virulence in mice. Gauthier, Y.P., Thibault, F.M., Paucod, J.C., Vidal, D.R. Acta Trop. (2000) [Pubmed]
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