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Gene Review

INPP1  -  inositol polyphosphate-1-phosphatase

Bos taurus

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Disease relevance of INPP1


High impact information on INPP1


Biological context of INPP1

  • These motifs may correspond to binding sites within IMP and IPP for inositol phosphates or for lithium, since both substances are bound by these proteins [7].

Anatomical context of INPP1


Associations of INPP1 with chemical compounds

  • Neither the oxygen-hemoglobin dissociation curve nor the Hill coefficient, n, of fetal or adult bovine hemoglobin was affected by uric acid riboside (UAR), 2,3-diphosphoglyceric acid (2,3-DPG), adenosine triphosphate (ATP), or inositol pentaphosphate (IPP) [10].

Analytical, diagnostic and therapeutic context of INPP1


  1. Crystallization and initial X-ray crystallographic characterization of recombinant bovine inositol polyphosphate 1-phosphatase produced in Spodoptera frugiperda cells. York, J.D., Chen, Z.W., Ponder, J.W., Chauhan, A.K., Mathews, F.S., Majerus, P.W. J. Mol. Biol. (1994) [Pubmed]
  2. Lymphocyte subpopulations in jejunal and ileal Peyer's patches of calves with experimental Salmonella dublin infection. Liebler, E.M., Press, C.M., Landsverk, T. Zentralblatt Veterinarmedizin Reihe B (1994) [Pubmed]
  3. Isolation and heterologous expression of a cDNA encoding bovine inositol polyphosphate 1-phosphatase. York, J.D., Majerus, P.W. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  4. Inositol polyphosphate 1-phosphatase is present in the nucleus and inhibits DNA synthesis. York, J.D., Saffitz, J.E., Majerus, P.W. J. Biol. Chem. (1994) [Pubmed]
  5. Properties of inositol polyphosphate 1-phosphatase. Inhorn, R.C., Majerus, P.W. J. Biol. Chem. (1988) [Pubmed]
  6. The metabolism of inositol 1,3,4-trisphosphate to inositol 1,3-bisphosphate. Bansal, V.S., Inhorn, R.C., Majerus, P.W. J. Biol. Chem. (1987) [Pubmed]
  7. Diverse proteins homologous to inositol monophosphatase. Neuwald, A.F., York, J.D., Majerus, P.W. FEBS Lett. (1991) [Pubmed]
  8. [3H]inositol polyphosphate metabolism in muscarinic cholinoceptor-stimulated airways smooth muscle: accumulation of [3H]inositol 4,5 bisphosphate via a lithium-sensitive inositol polyphosphate 1-phosphatase. Lynch, B.J., Muqit, M.M., Walker, T.R., Chilvers, E.R. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  9. Postnatal evolution of lymphocyte subpopulations in peripheral blood and lymphoid organs in the goat. Caro, M.R., Gallego, M.C., Buendía, A.J., Navarro, E., Navarro, J.A. Res. Vet. Sci. (1998) [Pubmed]
  10. Oxygen binding of fetal and adult bovine hemoglobin in the presence of organic phosphates and uric acid riboside. Smith, R.C., Garbutt, G.J., Isaacks, R.E., Harkness, D.R. Hemoglobin (1979) [Pubmed]
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