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Gene Review

INPP1  -  inositol polyphosphate-1-phosphatase

Homo sapiens

Synonyms: IPP, IPPase, Inositol polyphosphate 1-phosphatase
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Disease relevance of INPP1

  • This is the first study to report the upregulation of the INPP1 gene in a human cancer and should facilitate further studies looking at the role of phosphatidylinositol signaling reactions in human colorectal cancer [1].
  • Hypertrophied cells from both cell models as well as ventricular tissue from mouse hearts hypertrophied by pressure overload in vivo contained heightened levels of Ins(1,4)P(2), suggesting reduced INPP activity in three different models of hypertrophy [2].
  • Other than a tendency toward a larger MOV, a higher incidence of oligomenorrhea, obesity, and frequency of neurological disorders, recovery of the reproductive axis after GnRH analog therapy was not markedly different in HH compared to IPP [3].
  • We studied 65 children with either idiopathic (IPP; n = 50 girls and 3 boys) or neurogenic central precocious puberty (NPP; n = 5 girls and 7 boys) [4].
  • Seizure disorders developed during GnRH analog therapy in 5 HH and 1 IPP patient, and 2 additional HH girls developed severe depression and emotional lability posttherapy [3].

Psychiatry related information on INPP1


High impact information on INPP1


Chemical compound and disease context of INPP1


Biological context of INPP1

  • We report the genomic structure and organization of the INPP1 gene on chromosome 2q32 [12].
  • Based on DNA sequencing of the entire genomic region containing INPP1, we found that the gene consists of six exons and spans more than 25 kb [12].
  • Intriguingly, Drosophila mutants lacking IPPase activity display a defect in synaptic transmission, and this alteration could be phenocopied by lithium exposure [12].
  • Marked obesity (BMI, +2 to +5.2 SD score) was observed in 5 HH and 6 IPP patients, 1 of whom had a BMI of +2.5 SD score and developed acanthosis nigricans, insulin resistance, and hyperglycemia [3].
  • Live births of normal infants were reported by 2 HH and 2 IPP patients, and elective terminations of pregnancy were reported by 1 HH and 2 IPP patients [3].

Anatomical context of INPP1

  • Expression analysis showed that INPP1 is present as a 1.9 kb mRNA transcript in all organs and tissues examined, including the central nervous system [12].
  • PURPOSE: The ease of the transscrotal approach for penile prosthesis implantation and the proximity of the urethra has allowed the evolution of a new strategy for dual implantation of an AUS and IPP at a single setting [13].
  • We have used suppression subtractive hybridization to demonstrate significant overexpression of the inositol polyphosphate 1-phosphatase gene (INPP1) in colorectal cancer compared with matched normal colon epithelium [1].
  • OBJECTIVES: To determine the effect of intravesical protrusion of the prostate (IPP, graded I to III) on lower urinary tract function, by correlating it with the results of a pressure-flow study [14].
  • Human erythrocytes incubated in inosine-pyruvate-phosphate (IPP) medium are able to accumulate great amounts of inosine monophosphate (IMP) and inosine triphosphate (ITP) [15].

Associations of INPP1 with chemical compounds


Analytical, diagnostic and therapeutic context of INPP1


  1. Transcription of the inositol polyphosphate 1-phosphatase gene (INPP1) is upregulated in human colorectal cancer. Li, S.R., Gyselman, V.G., Lalude, O., Dorudi, S., Bustin, S.A. Mol. Carcinog. (2000) [Pubmed]
  2. Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor. Woodcock, E.A., Wang, B.H., Arthur, J.F., Lennard, A., Matkovich, S.J., Du, X.J., Brown, J.H., Hannan, R.D. J. Biol. Chem. (2002) [Pubmed]
  3. Reproductive axis after discontinuation of gonadotropin-releasing hormone analog treatment of girls with precocious puberty: long term follow-up comparing girls with hypothalamic hamartoma to those with idiopathic precocious puberty. Feuillan, P.P., Jones, J.V., Barnes, K., Oerter-Klein, K., Cutler, G.B. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  4. Leptin levels in children with central precocious puberty. Palmert, M.R., Radovick, S., Boepple, P.A. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  5. Manic-depressive illness: an association study with the inositol polyphosphate 1-phosphatase and serotonin transporter genes. Piccardi, M.P., Ardau, R., Chillotti, C., Deleuze, J.F., Mallet, J., Meloni, R., Oi, A., Severino, G., Congiu, D., Bayorek, M., Del Zompo, M. Psychiatr. Genet. (2002) [Pubmed]
  6. Association of INPP1, PIK3CG, and TSC2 gene variants with autistic disorder: implications for phosphatidylinositol signalling in autism. Serajee, F.J., Nabi, R., Zhong, H., Mahbubul Huq, A.H. J. Med. Genet. (2003) [Pubmed]
  7. Health service use costs by personality disorder following specialist and nonspecialist treatment: a comparative study. Chiesa, M., Fonagy, P., Holmes, J., Drahorad, C., Harrison-Hall, A. J. Personal. Disord. (2002) [Pubmed]
  8. Recent insights in phosphatidylinositol signaling. Majerus, P.W., Ross, T.S., Cunningham, T.W., Caldwell, K.K., Jefferson, A.B., Bansal, V.S. Cell (1990) [Pubmed]
  9. Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure. York, J.D., Ponder, J.W., Majerus, P.W. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  10. Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase. York, J.D., Veile, R.A., Donis-Keller, H., Majerus, P.W. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  11. Association study of the INPP1, 5HTT, BDNF, AP-2beta and GSK-3beta GENE variants and restrospectively scored response to lithium prophylaxis in bipolar disorder. Michelon, L., Meira-Lima, I., Cordeiro, Q., Miguita, K., Breen, G., Collier, D., Vallada, H. Neurosci. Lett. (2006) [Pubmed]
  12. Genomic structure and sequence analysis of a human inositol polyphosphate 1-phosphatase gene (INPP1). Løvlie, R., Gulbrandsen, A.K., Molven, A., Steen, V.M. Pharmacogenetics (1999) [Pubmed]
  13. Synchronous prosthetic implantation through a transscrotal incision: an outcome analysis. Kendirci, M., Gupta, S., Shaw, K., Morey, A., Jones, L., Hakim, L., Hellstrom, W.J. J. Urol. (2006) [Pubmed]
  14. Correlation of intravesical prostatic protrusion with bladder outlet obstruction. Chia, S.J., Heng, C.T., Chan, S.P., Foo, K.T. BJU international. (2003) [Pubmed]
  15. Hypoxanthine nucleotides synthesis in fresh and stored human erythrocytes. Zachara, B., Klem, J., Kopff, M. Acta Biol. Med. Ger. (1981) [Pubmed]
  16. Lithium long-term treatment in mood disorders: clinical and genetic predictors. Serretti, A. Pharmacogenomics (2002) [Pubmed]
  17. A novel mammalian lithium-sensitive enzyme with a dual enzymatic activity, 3'-phosphoadenosine 5'-phosphate phosphatase and inositol-polyphosphate 1-phosphatase. López-Coronado, J.M., Bellés, J.M., Lesage, F., Serrano, R., Rodríguez, P.L. J. Biol. Chem. (1999) [Pubmed]
  18. Inositol polyphosphate 1-phosphatase is present in the nucleus and inhibits DNA synthesis. York, J.D., Saffitz, J.E., Majerus, P.W. J. Biol. Chem. (1994) [Pubmed]
  19. Circular dichroism and fluorescence studies on the binding of ligands to the alpha subunit of tryptophan synthase. Heyn, M.P., Weischet, W.O. Biochemistry (1975) [Pubmed]
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