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Gene Review:

Kif1b - kinesin family member 1B

Mus musculus

Synonyms: A530096N05Rik, AI448212, AI506502, D4Mil1e, KIF1Bp130, ...

Yang, H.W. et al., Gong, T.W. et al., Conforti, L. et al.

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High impact information on Kif1b

We performed mutational analysis of the KIF1B-beta gene in 23 cell lines using 46 sets of primers and also an allelic imbalance (AI) analysis of KIF1B-beta in 50 fresh NB samples [1].
The KIF1B-beta gene had at least 47 exons, all of which had a classic exon-intron boundary structure [1].
These results suggest that the KIF1B-beta gene may not be a candidate for tumor suppressor gene of NB [1].
We conclude, therefore, that the Kif1b gene generates two major kinesin isoforms by alternative splicing [2].
There is, however, no evidence that Kif1b is the Wld gene [3].

Biological context of Kif1b

In addition, alternative splicing of two exons in the conserved region adjacent to the motor domain generates four different isoforms of each kinesin, leading to eight kinesin isoforms derived from the Kif1b gene [2].
We found a approximately 480 kb homozygously deleted region at chromosome band 1p36.2 in one of the 24 NB cell lines, NB-1, and cloned the human homologue (KIF1B-beta) of the mouseKif1B-beta gene in this region [1].

References

Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2. Yang, H.W., Chen, Y.Z., Takita, J., Soeda, E., Piao, H.Y., Hayashi, Y. Oncogene (2001) [Pubmed]
A novel mouse kinesin of the UNC-104/KIF1 subfamily encoded by the Kif1b gene. Gong, T.W., Winnicki, R.S., Kohrman, D.C., Lomax, M.I. Gene (1999) [Pubmed]
The major brain isoform of kif1b lacks the putative mitochondria-binding domain. Conforti, L., Buckmaster, E.A., Tarlton, A., Brown, M.C., Lyon, M.F., Perry, V.H., Coleman, M.P. Mamm. Genome (1999) [Pubmed]

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