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Gene Review:

PKD1L1 - polycystic kidney disease 1 like 1

Homo sapiens

Synonyms: PC1-like 1 protein, PRO19563, Polycystic kidney disease protein 1-like 1, Polycystin-1L1, UNQ5785/PRO19563

Yuasa, T. et al., Li, A. et al.

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High impact information on PKD1L1

Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes [1].
Dot-blot analysis and RT-PCR revealed that human PKD1L1 is expressed in testis and in fetal and adult heart [2].
We have assigned PKD1L1 to the short arm of human chromosome 7 in bands p12--p13 and Pkd1l1 to mouse chromosome 11 in band A2 by fluorescence in situ hybridization [2].
The full-length cDNA sequence of PKD1L1, determined from human testis cDNA, encodes a 2849-amino-acid protein and 58 exons in a 187-kb genomic region [2].
The deduced amino acid sequence of polycystin-1L1 has significant homology with all known polycystins, but the longest stretches of homology were found with polycystin-1 and -REJ over the 1453- and 932-amino-acid residues, respectively [2].

References

Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes. Li, A., Tian, X., Sung, S.W., Somlo, S. Genomics (2003) [Pubmed]
The sequence, expression, and chromosomal localization of a novel polycystic kidney disease 1-like gene, PKD1L1, in human. Yuasa, T., Venugopal, B., Weremowicz, S., Morton, C.C., Guo, L., Zhou, J. Genomics (2002) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

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LOC100492056	Xenopus (Silurana) tropicalis

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