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Gene Review:

Lgals6 - lectin, galactose binding, soluble 6

Mus musculus

Synonyms: Gal-6, Galectin-6, galectin-6

Marková, V. et al., Wooters, M.A. et al., Gitt, M.A. et al., Gitt, M.A. et al.

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High impact information on Lgals6

Both Lgals6 and the closely related Lgals4 are clustered together about 3.2 centimorgans proximal to the apoE gene on mouse chromosome 7 [1].
The coding sequence of galectin-6 is specified by eight exons [1].

Biological context of Lgals6

Galectin-4 and its homologue galectin-6 are members of the tandem-repeat subfamily of monomer divalent galectins [2].

Anatomical context of Lgals6

Galectin-4 and galectin-6 are two closely related lectins expressed in mouse gastrointestinal tract [3].
Expression of both galectin-4 and galectin-6 is confined to the epithelial cells of the embryonic and adult gastrointestinal tract [3].
To determine if a porcine homolog of murine galectin-6 is expressed in small intestine, primers for a reverse transcriptase-polymerase chain reaction (RT-PCR) were developed that amplified across the linker region of galectin-4, which is the region that differs between murine galectins-4 and -6 [4].

Associations of Lgals6 with chemical compounds

To study the role of carbohydrate recognition domains (CRDs) in oligosaccharide binding and epitope recognition, we cloned mouse full-length galectin-4 and galectin-6 cDNA and constructed bacterial expression vectors producing histidin-tagged recombinant galectin-4 and its truncated CRD1 and CRD2 forms [2].

Physical interactions of Lgals6

Role of the carbohydrate recognition domains of mouse galectin-4 in oligosaccharide binding and epitope recognition and expression of galectin-4 and galectin-6 in mouse cells and tissues [2].

References

Sequence, structure, and chromosomal mapping of the mouse Lgals6 gene, encoding galectin-6. Gitt, M.A., Xia, Y.R., Atchison, R.E., Lusis, A.J., Barondes, S.H., Leffler, H. J. Biol. Chem. (1998) [Pubmed]
Role of the carbohydrate recognition domains of mouse galectin-4 in oligosaccharide binding and epitope recognition and expression of galectin-4 and galectin-6 in mouse cells and tissues. Marková, V., Smetana, K., Jeníková, G., Láchová, J., Krejciríková, V., Poplstein, M., Fábry, M., Brynda, J., Alvarez, R.A., Cummings, R.D., Maly, P. Int. J. Mol. Med. (2006) [Pubmed]
Galectin-4 and galectin-6 are two closely related lectins expressed in mouse gastrointestinal tract. Gitt, M.A., Colnot, C., Poirier, F., Nani, K.J., Barondes, S.H., Leffler, H. J. Biol. Chem. (1998) [Pubmed]
Identification of galectin-4 isoforms in porcine small intestine. Wooters, M.A., Ropp, S.L., Erickson, A.K. Biochimie (2005) [Pubmed]

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