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Gene Review:

Lgals4 - lectin, galactose binding, soluble 4

Mus musculus

Synonyms: Gal-4, Galectin-4, Lactose-binding lectin 4, galectin-4

Marková, V. et al., Wooters, M.A. et al., Gitt, M.A. et al., Hokama, A. et al., Gitt, M.A. et al., et al.

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Disease relevance of Lgals4

The galectin-4-mediated stimulation of CD4(+) T cells is shown to exacerbate chronic colitis and delay the recovery from acute intestinal injury [1].

High impact information on Lgals4

Interestingly, the reactivity of CD4(+) T cells to galectin-4 is precisely elicited under intestinal inflammatory conditions [1].
Both Lgals6 and the closely related Lgals4 are clustered together about 3.2 centimorgans proximal to the apoE gene on mouse chromosome 7 [2].
In the course of studying mouse colon mRNA for galectin-4, we detected a related mRNA that encodes a new galectin that also has two CRDs in a single peptide chain [3].
Galectin-4 and galectin-6 are two closely related lectins expressed in mouse gastrointestinal tract [3].
Expression of both galectin-4 and galectin-6 is confined to the epithelial cells of the embryonic and adult gastrointestinal tract [3].

Biological context of Lgals4

2. Based on nucleotide sequence similarities, the two isoforms are likely splice variants of galectin-4 pre-mRNA and not products of separate genes like murine galectins-4 and -6 [4].
Amino acid sequence analysis of peptides generated by CNBr cleavage of the 34-kDa protein, the most abundant of these proteins, identified this protein as porcine galectin-4 [4].
Galectin-4 and its homologue galectin-6 are members of the tandem-repeat subfamily of monomer divalent galectins [5].

Anatomical context of Lgals4

Identification of galectin-4 isoforms in porcine small intestine [4].
In the large intestine, galectin-4/6 predominated, and the upper half of crypts simultaneously contained transcripts of galectin-3 [6].
Galectin-4 is expressed in spermatozoons and oocytes and its expression during early mouse emryogenesis appears in 8-cell embryos and remains in later stages, as tested by RT-PCR [5].

Associations of Lgals4 with chemical compounds

To study the role of carbohydrate recognition domains (CRDs) in oligosaccharide binding and epitope recognition, we cloned mouse full-length galectin-4 and galectin-6 cDNA and constructed bacterial expression vectors producing histidin-tagged recombinant galectin-4 and its truncated CRD1 and CRD2 forms [5].

Analytical, diagnostic and therapeutic context of Lgals4

Using these primers, this RT-PCR approach identified two galectin-4 isoforms that differed in the length of their linker region [4].

References

Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation. Hokama, A., Mizoguchi, E., Sugimoto, K., Shimomura, Y., Tanaka, Y., Yoshida, M., Rietdijk, S.T., de Jong, Y.P., Snapper, S.B., Terhorst, C., Blumberg, R.S., Mizoguchi, A. Immunity (2004) [Pubmed]
Sequence, structure, and chromosomal mapping of the mouse Lgals6 gene, encoding galectin-6. Gitt, M.A., Xia, Y.R., Atchison, R.E., Lusis, A.J., Barondes, S.H., Leffler, H. J. Biol. Chem. (1998) [Pubmed]
Galectin-4 and galectin-6 are two closely related lectins expressed in mouse gastrointestinal tract. Gitt, M.A., Colnot, C., Poirier, F., Nani, K.J., Barondes, S.H., Leffler, H. J. Biol. Chem. (1998) [Pubmed]
Identification of galectin-4 isoforms in porcine small intestine. Wooters, M.A., Ropp, S.L., Erickson, A.K. Biochimie (2005) [Pubmed]
Role of the carbohydrate recognition domains of mouse galectin-4 in oligosaccharide binding and epitope recognition and expression of galectin-4 and galectin-6 in mouse cells and tissues. Marková, V., Smetana, K., Jeníková, G., Láchová, J., Krejciríková, V., Poplstein, M., Fábry, M., Brynda, J., Alvarez, R.A., Cummings, R.D., Maly, P. Int. J. Mol. Med. (2006) [Pubmed]
Differential cellular expression of galectin family mRNAs in the epithelial cells of the mouse digestive tract. Nio, J., Kon, Y., Iwanaga, T. J. Histochem. Cytochem. (2005) [Pubmed]

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