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Gene Review

Lgals4  -  lectin, galactose binding, soluble 4

Mus musculus

Synonyms: Gal-4, Galectin-4, Lactose-binding lectin 4, galectin-4
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Disease relevance of Lgals4

  • The galectin-4-mediated stimulation of CD4(+) T cells is shown to exacerbate chronic colitis and delay the recovery from acute intestinal injury [1].

High impact information on Lgals4


Biological context of Lgals4


Anatomical context of Lgals4


Associations of Lgals4 with chemical compounds

  • To study the role of carbohydrate recognition domains (CRDs) in oligosaccharide binding and epitope recognition, we cloned mouse full-length galectin-4 and galectin-6 cDNA and constructed bacterial expression vectors producing histidin-tagged recombinant galectin-4 and its truncated CRD1 and CRD2 forms [5].

Analytical, diagnostic and therapeutic context of Lgals4

  • Using these primers, this RT-PCR approach identified two galectin-4 isoforms that differed in the length of their linker region [4].


  1. Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation. Hokama, A., Mizoguchi, E., Sugimoto, K., Shimomura, Y., Tanaka, Y., Yoshida, M., Rietdijk, S.T., de Jong, Y.P., Snapper, S.B., Terhorst, C., Blumberg, R.S., Mizoguchi, A. Immunity (2004) [Pubmed]
  2. Sequence, structure, and chromosomal mapping of the mouse Lgals6 gene, encoding galectin-6. Gitt, M.A., Xia, Y.R., Atchison, R.E., Lusis, A.J., Barondes, S.H., Leffler, H. J. Biol. Chem. (1998) [Pubmed]
  3. Galectin-4 and galectin-6 are two closely related lectins expressed in mouse gastrointestinal tract. Gitt, M.A., Colnot, C., Poirier, F., Nani, K.J., Barondes, S.H., Leffler, H. J. Biol. Chem. (1998) [Pubmed]
  4. Identification of galectin-4 isoforms in porcine small intestine. Wooters, M.A., Ropp, S.L., Erickson, A.K. Biochimie (2005) [Pubmed]
  5. Role of the carbohydrate recognition domains of mouse galectin-4 in oligosaccharide binding and epitope recognition and expression of galectin-4 and galectin-6 in mouse cells and tissues. Marková, V., Smetana, K., Jeníková, G., Láchová, J., Krejciríková, V., Poplstein, M., Fábry, M., Brynda, J., Alvarez, R.A., Cummings, R.D., Maly, P. Int. J. Mol. Med. (2006) [Pubmed]
  6. Differential cellular expression of galectin family mRNAs in the epithelial cells of the mouse digestive tract. Nio, J., Kon, Y., Iwanaga, T. J. Histochem. Cytochem. (2005) [Pubmed]
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