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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

BHLHA15  -  basic helix-loop-helix family, member a15

Homo sapiens

Synonyms: BHLHB8, Class A basic helix-loop-helix protein 15, Class B basic helix-loop-helix protein 8, MIST-1, MIST1, ...
 
 
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Disease relevance of BHLHB8

 

High impact information on BHLHB8

  • Here, we describe a gene expression analysis of laser capture microdissection purified gastric cell populations that identified the bHLH transcription factor Mist1 as a potential ZC regulatory factor [2].
  • Mist1 null (Mist1(KO)) lactating mammary glands were defective in normal lobuloalveolar organization, exhibiting shedding of cells into the alveolus lumen and premature activation of the signal transducer and activator of transcription 3 signaling pathway [3].
  • Our findings suggest that loss of Mist1 impairs the maintenance of the fully differentiated alveolar state and, for the first time, places Mist1 within the hierarchy of known HLH/bHLH proteins that control mammary epithelial cell development [3].
 

Anatomical context of BHLHB8

  • In this study, we identify Mist1 as a tissue-restricted Class II bHLH transcription factor expressed in lactating mammary glands [3].

References

  1. A review of ipratropium bromide/fenoterol hydrobromide (Berodual) delivered via Respimat Soft Mist Inhaler in patients with asthma and chronic obstructive pulmonary disease. Kässner, F., Hodder, R., Bateman, E.D. Drugs (2004) [Pubmed]
  2. The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1. Ramsey, V.G., Doherty, J.M., Chen, C.C., Stappenbeck, T.S., Konieczny, S.F., Mills, J.C. Development (2007) [Pubmed]
  3. Identification of a basic helix-loop-helix transcription factor expressed in mammary gland alveolar cells and required for maintenance of the differentiated state. Zhao, Y., Johansson, C., Tran, T., Bettencourt, R., Itahana, Y., Desprez, P.Y., Konieczny, S.F. Mol. Endocrinol. (2006) [Pubmed]
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