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Gene Review

OIT3  -  oncoprotein induced transcript 3

Homo sapiens

Synonyms: FLJ39116, LZP, Liver-specific zona pellucida domain-containing protein, Oncoprotein-induced transcript 3 protein, UNQ826/PRO1753
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Psychiatry related information on OIT3

  • In more than 400 patients suffering from generalized anxiety or adjustment disorders with anxious mood, six double-blind studies run against placebo or reference drug over a period of two to three weeks indicated an anxiolytic effect superior (P less than 0.01) to that of placebo and comparable to that of reference drugs (DZ, LZP, CZP) [1].

High impact information on OIT3

  • The full-length complementary DNA (cDNA) of human LZP has 2,255 bp with a complete open reading frame (ORF) of 1,635 bp [2].
  • We currently identified a liver-specific gene that encodes a novel zona pellucida (ZP) domain-containing protein named liver-specific ZP domain-containing protein (LZP) [2].
  • Moreover, LZP can be secreted into blood, albeit the protein was localized mainly on the nuclear envelop of hepatocytes [2].
  • Interestingly, human LZP is expressed specifically in liver out of 23 tissues examined, and its mouse counterpart was detected at very early stage during embryo development [2].
  • Identification and characterization of D8C, a novel domain present in liver-specific LZP, uromodulin and glycoprotein 2, mutated in familial juvenile hyperuricaemic nephropathy [3].

Associations of OIT3 with chemical compounds

  • Using this tool, the dataset obtained from cells treated with LPS and LZP were separated from those obtained from LZ treated cells [4].
  • This inhibition was counteracted by addition of the beta(2)-AR antagonist propranolol (LZP) [4].


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