The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Zona Pellucida

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Zona Pellucida


High impact information on Zona Pellucida

  • We report the identification of SED1, a protein required for mouse sperm binding to the egg zona pellucida [6].
  • In the mouse, the zona pellucida (ZP) glycoprotein ZP3 both binds intact sperm and induces acrosomal exocytosis [7].
  • Antisera from immunized females had high titres, specifically recognized PH-20 in sperm extracts, and blocked sperm adhesion to the egg zona pellucida in vitro [8].
  • These receptors include the receptor tyrosine kinases that mediate the actions of growth factors such as epidermal growth factor, insulin, insulin-like growth factor as well as receptors for atrial natiuretic hormone or the zona pellucida protein (ZP3) and integrins [9].
  • Interaction of a tyrosine kinase from human sperm with the zona pellucida at fertilization [10].

Chemical compound and disease context of Zona Pellucida


Biological context of Zona Pellucida

  • Oocyte-specific gene expression: molecular characterization of a cDNA coding for ZP-3, the sperm receptor of the mouse zona pellucida [15].
  • The structural defect is more severe than that observed in Zp1-null mice, which have decreased fecundity, but not quite as severe as that observed in Zp3-null mice, which never form a visible zona pellucida and are sterile [16].
  • These data indicate that the delayed sperm penetration of the zona pellucida in the Acr-/- mouse results from the altered rate of protein dispersal from the acrosome and provide the first evidence that the major role of acrosin is to accelerate the dispersal of acrosomal components during acrosome reaction [17].
  • Although Acr-/- mouse sperm lacking the acrosin protease activity still penetrated the zona pellucida and fertilized the egg, the mutant sperm exhibited a delay in penetration of the zona pellucida solely at the early stages after insemination [17].
  • Exons 2-7 share homology with the zona pellucida protein genes rc55 of rabbit and zp-2 of mouse, and the positions of intron boundaries are conserved in the wf female and mouse zp-2 genes [18].

Anatomical context of Zona Pellucida


Associations of Zona Pellucida with chemical compounds


Gene context of Zona Pellucida

  • The 13 SRCR domains are followed by two C1r/C1s Uegf Bmp1 domains separated by a 14th SRCR domain and a zona pellucida domain. gp-340 seems to be an alternative spliced form of DMBT1 [27].
  • An observed post-fertilization persistence of mouse sperm binding to "humanized" zona pellucida correlates with uncleaved ZP2 [28].
  • FIGalpha, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes [29].
  • The mouse zona pellucida contains three glycoproteins, ZP1, ZP2, and ZP3, which are conserved in rat and human [30].
  • Mouse Zp1 encodes a zona pellucida protein homologous to egg envelope proteins in mammals and fish [31].

Analytical, diagnostic and therapeutic context of Zona Pellucida


  1. The putative chaperone calmegin is required for sperm fertility. Ikawa, M., Wada, I., Kominami, K., Watanabe, D., Toshimori, K., Nishimune, Y., Okabe, M. Nature (1997) [Pubmed]
  2. Antigen mimicry in autoimmune disease sharing of amino acid residues critical for pathogenic T cell activation. Luo, A.M., Garza, K.M., Hunt, D., Tung, K.S. J. Clin. Invest. (1993) [Pubmed]
  3. Autoimmune disease of the ovary induced by a ZP3 peptide from the mouse zona pellucida. Rhim, S.H., Millar, S.E., Robey, F., Luo, A.M., Lou, Y.H., Yule, T., Allen, P., Dean, J., Tung, K.S. J. Clin. Invest. (1992) [Pubmed]
  4. Roles of heterotrimeric and monomeric G proteins in sperm-induced activation of mouse eggs. Moore, G.D., Ayabe, T., Visconti, P.E., Schultz, R.M., Kopf, G.S. Development (1994) [Pubmed]
  5. A zona pellucida 3 peptide vaccine induces antibodies and reversible infertility without ovarian pathology. Lou, Y., Ang, J., Thai, H., McElveen, F., Tung, K.S. J. Immunol. (1995) [Pubmed]
  6. Identification of mouse sperm SED1, a bimotif EGF repeat and discoidin-domain protein involved in sperm-egg binding. Ensslin, M.A., Shur, B.D. Cell (2003) [Pubmed]
  7. 95 kd sperm proteins bind ZP3 and serve as tyrosine kinase substrates in response to zona binding. Leyton, L., Saling, P. Cell (1989) [Pubmed]
  8. Fully effective contraception in male and female guinea pigs immunized with the sperm protein PH-20. Primakoff, P., Lathrop, W., Woolman, L., Cowan, A., Myles, D. Nature (1988) [Pubmed]
  9. Single transmembrane spanning heterotrimeric g protein-coupled receptors and their signaling cascades. Patel, T.B. Pharmacol. Rev. (2004) [Pubmed]
  10. Interaction of a tyrosine kinase from human sperm with the zona pellucida at fertilization. Burks, D.J., Carballada, R., Moore, H.D., Saling, P.M. Science (1995) [Pubmed]
  11. Induction of the human sperm acrosome reaction with mannose-containing neoglycoprotein ligands. Benoff, S., Hurley, I.R., Mandel, F.S., Cooper, G.W., Hershlag, A. Mol. Hum. Reprod. (1997) [Pubmed]
  12. Calcium influx into mouse spermatozoa activated by solubilized mouse zona pellucida, monitored with the calcium fluorescent indicator, fluo-3. Inhibition of the influx by three inhibitors of the zona pellucida induced acrosome reaction: tyrphostin A48, pertussis toxin, and 3-quinuclidinyl benzilate. Bailey, J.L., Storey, B.T. Mol. Reprod. Dev. (1994) [Pubmed]
  13. A cysteine substitution in the zona pellucida domain of alpha-tectorin results in autosomal dominant, postlingual, progressive, mid frequency hearing loss in a Spanish family. Moreno-Pelayo, M.A., del Castillo, I., Villamar, M., Romero, L., Hernández-Calvín, F.J., Herraiz, C., Barberá, R., Navas, C., Moreno, F. J. Med. Genet. (2001) [Pubmed]
  14. Postovulatory effect of intravenous administration of lipopolysaccharide (E. coli, O55:B5) on the contractile activity of the oviduct, ova transport, binding of accessory spermatozoa to the zona pellucida and embryo development in sows. Mwanza, A.M., Rodríguez-Martínez, H., Kindahl, H., Einarsson, S. Reprod. Domest. Anim. (2002) [Pubmed]
  15. Oocyte-specific gene expression: molecular characterization of a cDNA coding for ZP-3, the sperm receptor of the mouse zona pellucida. Ringuette, M.J., Sobieski, D.A., Chamow, S.M., Dean, J. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  16. Defective zonae pellucidae in Zp2-null mice disrupt folliculogenesis, fertility and development. Rankin, T.L., O'Brien, M., Lee, E., Wigglesworth, K., Eppig, J., Dean, J. Development (2001) [Pubmed]
  17. Acrosin accelerates the dispersal of sperm acrosomal proteins during acrosome reaction. Yamagata, K., Murayama, K., Okabe, M., Toshimori, K., Nakanishi, T., Kashiwabara, S., Baba, T. J. Biol. Chem. (1998) [Pubmed]
  18. Expression and structural analysis of a teleost homolog of a mammalian zona pellucida gene. Lyons, C.E., Payette, K.L., Price, J.L., Huang, R.C. J. Biol. Chem. (1993) [Pubmed]
  19. Complementarity between sperm surface beta-1,4-galactosyltransferase and egg-coat ZP3 mediates sperm-egg binding. Miller, D.J., Macek, M.B., Shur, B.D. Nature (1992) [Pubmed]
  20. Vaccination with a synthetic zona pellucida peptide produces long-term contraception in female mice. Millar, S.E., Chamow, S.M., Baur, A.W., Oliver, C., Robey, F., Dean, J. Science (1989) [Pubmed]
  21. Exocytosis in spermatozoa in response to progesterone and zona pellucida. Roldan, E.R., Murase, T., Shi, Q.X. Science (1994) [Pubmed]
  22. Trp2 regulates entry of Ca2+ into mouse sperm triggered by egg ZP3. Jungnickel, M.K., Marrero, H., Birnbaumer, L., Lémos, J.R., Florman, H.M. Nat. Cell Biol. (2001) [Pubmed]
  23. A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg. Lin, Y., Mahan, K., Lathrop, W.F., Myles, D.G., Primakoff, P. J. Cell Biol. (1994) [Pubmed]
  24. Novel alpha-D-mannosidase of rat sperm plasma membranes: characterization and potential role in sperm-egg interactions. Tulsiani, D.R., Skudlarek, M.D., Orgebin-Crist, M.C. J. Cell Biol. (1989) [Pubmed]
  25. A role for mouse sperm surface galactosyltransferase in sperm binding to the egg zona pellucida. Shur, B.D., Hall, N.G. J. Cell Biol. (1982) [Pubmed]
  26. Receptor function of mouse sperm surface galactosyltransferase during fertilization. Lopez, L.C., Bayna, E.M., Litoff, D., Shaper, N.L., Shaper, J.H., Shur, B.D. J. Cell Biol. (1985) [Pubmed]
  27. Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D. Holmskov, U., Mollenhauer, J., Madsen, J., Vitved, L., Gronlund, J., Tornoe, I., Kliem, A., Reid, K.B., Poustka, A., Skjodt, K. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  28. Reassessing the molecular biology of sperm-egg recognition with mouse genetics. Dean, J. Bioessays (2004) [Pubmed]
  29. FIGalpha, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes. Liang, L., Soyal, S.M., Dean, J. Development (1997) [Pubmed]
  30. Human sperm do not bind to rat zonae pellucidae despite the presence of four homologous glycoproteins. Hoodbhoy, T., Joshi, S., Boja, E.S., Williams, S.A., Stanley, P., Dean, J. J. Biol. Chem. (2005) [Pubmed]
  31. Mouse Zp1 encodes a zona pellucida protein homologous to egg envelope proteins in mammals and fish. Epifano, O., Liang, L.F., Dean, J. J. Biol. Chem. (1995) [Pubmed]
  32. Isolation, physicochemical properties, and macromolecular composition of zona pellucida from porcine oocytes. Dunbar, B.S., Wardrip, N.J., Hedrick, J.L. Biochemistry (1980) [Pubmed]
  33. Molecular cloning and characterization of P47, a novel boar sperm-associated zona pellucida-binding protein homologous to a family of mammalian secretory proteins. Ensslin, M., Vogel, T., Calvete, J.J., Thole, H.H., Schmidtke, J., Matsuda, T., Töpfer-Petersen, E. Biol. Reprod. (1998) [Pubmed]
  34. Isolation and preliminary characterization of a purified pig zona antigen (PPZA) from porcine oocytes. Yurewicz, E.C., Sacco, A.G., Subramanian, M.G. Biol. Reprod. (1983) [Pubmed]
  35. Complete activation of porcine oocytes induced by the sulfhydryl reagent, thimerosal. Macháty, Z., Wang, W.H., Day, B.N., Prather, R.S. Biol. Reprod. (1997) [Pubmed]
  36. Autoradiographic localization of specific binding of meiosis-activating sterol to cumulus-oocyte complexes from marmoset, cow, and mouse. Faerge, I., Grøndahl, C., Ottesen, J.L., Hyttel, P. Biol. Reprod. (2001) [Pubmed]
WikiGenes - Universities