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Gene Review:

PSORS1C1 - psoriasis susceptibility 1 candidate 1

Homo sapiens

Synonyms: C6orf16, Protein SEEK1, Psoriasis susceptibility 1 candidate gene 1 protein, SEEK1

Chang, Y.T. et al., Holm, S.J. et al., Rahman, P. et al., Shigenari, A. et al., Peddle, L. et al.

Chang, Liu, Shiao, Lin, Lee, Liu, Wang, Wu, Lai, Tsai, Rahman, Butt, Siannis, Farewell, Peddle, Pellett, Schentag, Gladman,

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Disease relevance of PSORS1C1

Up to the present, no association study of the PSORS1C1 gene has been conducted on Chinese patients with psoriasis [1].
Association of SEEK1 polymorphisms in Crohn's disease [2].
Association of SEEK1 and psoriatic arthritis in two distinct Canadian populations [3].

High impact information on PSORS1C1

This association is probably due to linkage disequilibrium between SEEK1 and HLA-Cw*0602 in this population [3].
A study of PSORS1C1 gene polymorphisms in Chinese patients with psoriasis [1].
RESULTS: We identified 10 single nucleotide polymorphisms (SNPs) on the PSORS1C1 gene in our subjects; four of these SNPs cause amino acid change [1].
OBJECTIVES: We aimed to determine whether the genetic polymorphisms of the PSORS1C1 gene were associated with an increased risk of psoriasis in Chinese patients [1].
The human SEEK1 and DPCR1 genes are pseudogenes in swine [4].

Biological context of PSORS1C1

We have characterized two overlapping genes, SEEK1 and SPR1 [5].

Analytical, diagnostic and therapeutic context of PSORS1C1

In a case-control study, five of the nine single nucleotide polymorphisms (SNPs) found in SEEK1 were associated with psoriasis, while one of the four SNPs found in SPR1 showed association [5].

References

A study of PSORS1C1 gene polymorphisms in Chinese patients with psoriasis. Chang, Y.T., Liu, H.N., Shiao, Y.M., Lin, M.W., Lee, D.D., Liu, M.T., Wang, W.J., Wu, S., Lai, C.Y., Tsai, S.F. Br. J. Dermatol. (2005) [Pubmed]
Association of SEEK1 polymorphisms in Crohn's disease. Peddle, L., Zipperlen, K., Melay, B., Hefferton, D., Rahman, P. Hum. Immunol. (2004) [Pubmed]
Association of SEEK1 and psoriatic arthritis in two distinct Canadian populations. Rahman, P., Butt, C., Siannis, F., Farewell, V.T., Peddle, L., Pellett, F.J., Schentag, C., Gladman, D.D. Ann. Rheum. Dis. (2005) [Pubmed]
Nucleotide sequencing analysis of the swine 433-kb genomic segment located between the non-classical and classical SLA class I gene clusters. Shigenari, A., Ando, A., Renard, C., Chardon, P., Shiina, T., Kulski, J.K., Yasue, H., Inoko, H. Immunogenetics (2004) [Pubmed]
Polymorphisms in the SEEK1 and SPR1 genes on 6p21.3 associate with psoriasis in the Swedish population. Holm, S.J., Carlén, L.M., Mallbris, L., Ståhle-Bäckdahl, M., O'Brien, K.P. Exp. Dermatol. (2003) [Pubmed]

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