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Gene Review

Cblb  -  Cbl proto-oncogene B, E3 ubiquitin protein...

Rattus norvegicus

Synonyms: Casitas B-lineage lymphoma proto-oncogene b, E3 ubiquitin-protein ligase CBL-B, SH3-binding protein CBL-B, Signal transduction protein CBL-B
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Disease relevance of Cblb


High impact information on Cblb

  • Similar findings in Cblb-deficient mice are caused by enhanced T-cell activation [1].
  • Transgenic complementation with wildtype Cblb significantly suppresses development of the KDP phenotype [1].
  • Thus, Cblb functions as a negative regulator of autoimmunity and Cblb is a major susceptibility gene for type 1 diabetes in the rat [1].
  • In this paper, I review our positional cloning analysis of Iddm/kdp1 and propose a two-gene model of the development of type 1 diabetes in which two major susceptibility genes, Cblb and MHC, determine autoimmune reaction and tissue specificity to pancreatic beta-cells, respectively [2].
  • The up-regulated genes included those coding Casitas B-lineage lymphoma-b, insulin growth factor binding protein-1, titin and mitochondrial gene 16 S rRNA and two novel genes (function unknown) [3].


  1. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Yokoi, N., Komeda, K., Wang, H.Y., Yano, H., Kitada, K., Saitoh, Y., Seino, Y., Yasuda, K., Serikawa, T., Seino, S. Nat. Genet. (2002) [Pubmed]
  2. Identification of a major gene responsible for type 1 diabetes in the Komeda diabetes-prone rat. Yokoi, N. Exp. Anim. (2005) [Pubmed]
  3. Isolation and characterization of a novel gene sfig in rat skeletal muscle up-regulated by spaceflight (STS-90). Kano, M., Kitano, T., Ikemoto, M., Hirasaka, K., Asanoma, Y., Ogawa, T., Takeda, S., Nonaka, I., Adams, G.R., Baldwin, K.M., Oarada, M., Kishi, K., Nikawa, T. J. Med. Invest. (2003) [Pubmed]
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