The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt

Table of contents

About

Terms

 

Gene Review: 

Cblb  -  Cbl proto-oncogene B, E3 ubiquitin protein...

Rattus norvegicus

Synonyms: Casitas B-lineage lymphoma proto-oncogene b, E3 ubiquitin-protein ligase CBL-B, SH3-binding protein CBL-B, Signal transduction protein CBL-B
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Cblb

 

High impact information on Cblb

  • Similar findings in Cblb-deficient mice are caused by enhanced T-cell activation [1].
  • Transgenic complementation with wildtype Cblb significantly suppresses development of the KDP phenotype [1].
  • Thus, Cblb functions as a negative regulator of autoimmunity and Cblb is a major susceptibility gene for type 1 diabetes in the rat [1].
  • In this paper, I review our positional cloning analysis of Iddm/kdp1 and propose a two-gene model of the development of type 1 diabetes in which two major susceptibility genes, Cblb and MHC, determine autoimmune reaction and tissue specificity to pancreatic beta-cells, respectively [2].
  • The up-regulated genes included those coding Casitas B-lineage lymphoma-b, insulin growth factor binding protein-1, titin and mitochondrial gene 16 S rRNA and two novel genes (function unknown) [3].

References

  1. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Yokoi, N., Komeda, K., Wang, H.Y., Yano, H., Kitada, K., Saitoh, Y., Seino, Y., Yasuda, K., Serikawa, T., Seino, S. Nat. Genet. (2002) [Pubmed]
  2. Identification of a major gene responsible for type 1 diabetes in the Komeda diabetes-prone rat. Yokoi, N. Exp. Anim. (2005) [Pubmed]
  3. Isolation and characterization of a novel gene sfig in rat skeletal muscle up-regulated by spaceflight (STS-90). Kano, M., Kitano, T., Ikemoto, M., Hirasaka, K., Asanoma, Y., Ogawa, T., Takeda, S., Nonaka, I., Adams, G.R., Baldwin, K.M., Oarada, M., Kishi, K., Nikawa, T. J. Med. Invest. (2003) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities