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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Vsx2  -  visual system homeobox 2

Rattus norvegicus

 
 
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High impact information on Chx10

  • Ectopic Chx10 expression drove bipolar instead of rod cell differentiation without affecting division [1].
  • Chx10 is required to block photoreceptor differentiation but is dispensable for progenitor proliferation in the postnatal retina [1].
  • In the Chx10-null ocular retardation (or(J)) mouse, retinal progenitor cell (RPC) proliferation is impaired, and bipolar neurons, a late born cell type, fail to differentiate [1].
  • GF-activated CB epithelial cells co-express the retinal progenitor homeodomain transcription factors Pax6 and Chx10 [2].

References

  1. Chx10 is required to block photoreceptor differentiation but is dispensable for progenitor proliferation in the postnatal retina. Livne-Bar, I., Pacal, M., Cheung, M.C., Hankin, M., Trogadis, J., Chen, D., Dorval, K.M., Bremner, R. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. In vivo reactivation of a quiescent cell population located in the ocular ciliary body of adult mammals. Abdouh, M., Bernier, G. Exp. Eye Res. (2006) [Pubmed]
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