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Gene Review

Trpm8  -  transient receptor potential cation...

Mus musculus

Synonyms: CMR1, LTRPC6, LTrpC-6, LTrpC6, Long transient receptor potential channel 6, ...
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High impact information on Trpm8

  • This cold- and menthol-sensitive receptor, CMR1, is a member of the TRP family of excitatory ion channels, and we propose that it functions as a transducer of cold stimuli in the somatosensory system [1].
  • The C-terminal residues of SIPP1, which do not conform to a classic nuclear export signal, were required for its nuclear export via the CMR-1 pathway [2].
  • Although a protein kinase C inhibitor blocked the response to TNF in both the brain MVEC, an inhibitor of protein kinase A selectively abolished the response to TNF in CM-R, but not CM-S brain MVEC, suggesting a differential protein kinase involvement in TNF-induced activation of CM-S and CM-R brain MVEC [3].
  • Although the constitutive expression of TNF receptors was comparable on cells from the two origins, TNF induced an up-regulation of both p55 and p75 TNF receptors in CM-S, but not in CM-R brain MVEC [3].
  • 1. TRPM8 (CMR1) is a Ca(2+)-permeable channel, which can be activated by low temperatures, menthol, eucalyptol and icilin [4].

Associations of Trpm8 with chemical compounds

  • These results indicate that brain MVEC purified from CM-S and CM-R mice exhibit distinctive sensitivity to TNF This difference may be partly due to a differential regulation of TNF receptors and via distinct protein kinase pathways [3].


  1. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. McKemy, D.D., Neuhausser, W.M., Julius, D. Nature (2002) [Pubmed]
  2. Nucleocytoplasmic shuttling of the splicing factor SIPP1. Llorian, M., Beullens, M., Lesage, B., Nicolaescu, E., Beke, L., Landuyt, W., Ortiz, J.M., Bollen, M. J. Biol. Chem. (2005) [Pubmed]
  3. Differential reactivity of brain microvascular endothelial cells to TNF reflects the genetic susceptibility to cerebral malaria. Lou, J., Gasche, Y., Zheng, L., Critico, B., Monso-Hinard, C., Juillard, P., Morel, P., Buurman, W.A., Grau, G.E. Eur. J. Immunol. (1998) [Pubmed]
  4. Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Behrendt, H.J., Germann, T., Gillen, C., Hatt, H., Jostock, R. Br. J. Pharmacol. (2004) [Pubmed]
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