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Gene Review

Hint1  -  histidine triad nucleotide binding protein 1

Mus musculus

Synonyms: AA673479, Adenosine 5'-monophosphoramidase, Hint, Histidine triad nucleotide-binding protein 1, Ipk1, ...
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Disease relevance of Hint1


High impact information on Hint1

  • We have also shown that Ap4A, an endogenous molecule consisting of two adenosine linked by four phosphate which is known to be synthesized by LysRS, is accumulated intracellularily above 700 microM in IgE-Ag-activated mast cells, binds to Hint, liberates MITF, and thus leads to the activation of MITF-dependent gene expression [6].
  • Cultured Purkinje cells prepared from heterozygous or homozygous L7-PKCI embryos showed a complete blockade of LTD induction [7].
  • In addition, the compensatory eye movements of L7-PKCI mice were recorded during vestibular and visual stimulation [7].
  • Whereas the absolute gain, phase, and latency values of the vestibulo-ocular reflex and optokinetic reflex of the L7-PKCI mice were normal, their ability to adapt their vestibulo-ocular reflex gain during visuo-vestibular training was absent [7].
  • GqPCR-induced inhibitions of I(GIRK) were not affected by protein kinase C inhibitor (calphostin C) but potentiated and became irreversible when the replenishment of PIP(2) was blocked by wortmannin (phosphatidylinositol kinase inhibitor) [8].

Biological context of Hint1


Anatomical context of Hint1


Associations of Hint1 with chemical compounds


Physical interactions of Hint1


Regulatory relationships of Hint1


Other interactions of Hint1


  1. Inhibition of induced acute lung edema by a novel protein kinase C inhibitor. Struhar, D., Harbeck, R.J. FASEB J. (1987) [Pubmed]
  2. Apoptosis induced by protein kinase C inhibition in a neuroblastoma cell line. Behrens, M.M., Martínez, J.L., Moratilla, C., Renart, J. Cell Growth Differ. (1995) [Pubmed]
  3. Membrane toxicity of the protein kinase C inhibitor calphostin A by a free-radical mechanism. Wang, S.S., Mathes, C., Thompson, S.H. Neurosci. Lett. (1993) [Pubmed]
  4. Effect of diabetes on bradykinin-induced thermal hyperalgesia in mice. Kamei, J., Ohsawa, M., Hitosugi, H. Eur. J. Pharmacol. (2000) [Pubmed]
  5. Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells. Ikegami, Y., Yano, S., Nakao, K. Jpn. J. Pharmacol. (1996) [Pubmed]
  6. The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells. Lee, Y.N., Nechushtan, H., Figov, N., Razin, E. Immunity (2004) [Pubmed]
  7. Expression of a protein kinase C inhibitor in Purkinje cells blocks cerebellar LTD and adaptation of the vestibulo-ocular reflex. De Zeeuw, C.I., Hansel, C., Bian, F., Koekkoek, S.K., van Alphen, A.M., Linden, D.J., Oberdick, J. Neuron (1998) [Pubmed]
  8. Receptor-induced depletion of phosphatidylinositol 4,5-bisphosphate inhibits inwardly rectifying K+ channels in a receptor-specific manner. Cho, H., Lee, D., Lee, S.H., Ho, W.K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  9. The histidine triad protein hint1 triggers apoptosis independent of its enzymatic activity. Weiske, J., Huber, O. J. Biol. Chem. (2006) [Pubmed]
  10. Wpkci, encoding an altered form of PKCI, is conserved widely on the avian W chromosome and expressed in early female embryos: implication of its role in female sex determination. Hori, T., Asakawa, S., Itoh, Y., Shimizu, N., Mizuno, S. Mol. Biol. Cell (2000) [Pubmed]
  11. Activation of microvascular endothelium by eicosanoid 12(S)-hydroxyeicosatetraenoic acid leads to enhanced tumor cell adhesion via up-regulation of surface expression of alpha v beta 3 integrin: a posttranscriptional, protein kinase C- and cytoskeleton-dependent process. Tang, D.G., Diglio, C.A., Honn, K.V. Cancer Res. (1994) [Pubmed]
  12. Regulation of Rac and Cdc42 pathways by G(i) during lysophosphatidic acid-induced cell spreading. Ueda, H., Morishita, R., Yamauchi, J., Itoh, H., Kato, K., Asano, T. J. Biol. Chem. (2001) [Pubmed]
  13. Role of calcium in pancreatic islet cell death by IFN-gamma/TNF-alpha. Chang, I., Cho, N., Kim, S., Kim, J.Y., Kim, E., Woo, J.E., Nam, J.H., Kim, S.J., Lee, M.S. J. Immunol. (2004) [Pubmed]
  14. Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action. Vigliotta, G., Miele, C., Santopietro, S., Portella, G., Perfetti, A., Maitan, M.A., Cassese, A., Oriente, F., Trencia, A., Fiory, F., Romano, C., Tiveron, C., Tatangelo, L., Troncone, G., Formisano, P., Beguinot, F. Mol. Cell. Biol. (2004) [Pubmed]
  15. Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells. Sako, T., Tauber, A.I., Jeng, A.Y., Yuspa, S.H., Blumberg, P.M. Cancer Res. (1988) [Pubmed]
  16. Protein kinase C regulates the phosphorylation and cellular localization of occludin. Andreeva, A.Y., Krause, E., Müller, E.C., Blasig, I.E., Utepbergenov, D.I. J. Biol. Chem. (2001) [Pubmed]
  17. Staurosporine induces tyrosine phosphorylation of a 145 kDa protein but does not activate gp140trk in PC12 cells. Rasouly, D., Lazarovici, P. Eur. J. Pharmacol. (1994) [Pubmed]
  18. The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription. Weiske, J., Huber, O. J. Cell. Sci. (2005) [Pubmed]
  19. Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation. Okoshi, H., Hakomori, S., Nisar, M., Zhou, Q.H., Kimura, S., Tashiro, K., Igarashi, Y. Cancer Res. (1991) [Pubmed]
  20. Interferon-gamma and interleukin-1 alpha induce transient translocation of protein kinase C activity to membranes in a B lymphoid cell line. Evidence for a protein kinase C-independent pathway in lymphokine-induced cytoplasmic alkalinization. Ostrowski, J., Meier, K.E., Stanton, T.H., Smith, L.L., Bomsztyk, K. J. Biol. Chem. (1988) [Pubmed]
  21. Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells. Laychock, S.G., Tian, Y., Sessanna, S.M. Diabetes (2003) [Pubmed]
  22. Phosphorylation of GTP cyclohydrolase I and modulation of its activity in rodent mast cells. GTP cyclohydrolase I hyperphosphorylation is coupled to high affinity IgE receptor signaling and involves protein kinase C. Hesslinger, C., Kremmer, E., Hültner, L., Ueffing, M., Ziegler, I. J. Biol. Chem. (1998) [Pubmed]
  23. Prolactin inhibits EGF-induced DNA synthesis in mammary epithelium via early signaling mechanisms: possible involvement of protein kinase C. Fenton, S.E., Sheffield, L.G. Exp. Cell Res. (1997) [Pubmed]
  24. Upregulation of interleukin-18 expression in mouse primary keratinocytes induced to differentiate by calcium. Kong, J., Li, Y.C. Arch. Dermatol. Res. (2002) [Pubmed]
  25. Evidence that interleukin-1 and phorbol esters activate NF-kappa B by different pathways: role of protein kinase C. Bomsztyk, K., Rooney, J.W., Iwasaki, T., Rachie, N.A., Dower, S.K., Sibley, C.H. Cell Regul. (1991) [Pubmed]
  26. The protein kinase C inhibitor H-7, inhibits antigen and IL-2-induced proliferation of murine T cell lines. Clark, R.B., Love, J.T., Sgroi, D., Lingenheld, E.G., Sha'afi, R.I. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  27. Suppression of microphthalmia transcriptional activity by its association with protein kinase C-interacting protein 1 in mast cells. Razin, E., Zhang, Z.C., Nechushtan, H., Frenkel, S., Lee, Y.N., Arudchandran, R., Rivera, J. J. Biol. Chem. (1999) [Pubmed]
  28. Bombesin, lysophosphatidic acid, and epidermal growth factor rapidly stimulate focal adhesion kinase phosphorylation at Ser-910: requirement for ERK activation. Hunger-Glaser, I., Salazar, E.P., Sinnett-Smith, J., Rozengurt, E. J. Biol. Chem. (2003) [Pubmed]
  29. Expression of prokineticin receptors in mouse cultured astrocytes and involvement in cell proliferation. Koyama, Y., Kiyo-Oka, M., Osakada, M., Horiguchi, N., Shintani, N., Ago, Y., Kakuda, M., Baba, A., Matsuda, T. Brain Res. (2006) [Pubmed]
  30. Interleukin-1beta induces chronic activation and de novo synthesis of neutral ceramidase in renal mesangial cells. Franzen, R., Pautz, A., Bräutigam, L., Geisslinger, G., Pfeilschifter, J., Huwiler, A. J. Biol. Chem. (2001) [Pubmed]
  31. Secretion of urokinase and metalloproteinase-9 induced by staurosporine is dependent on a tyrosine kinase pathway in mammary tumor cells. Aguirre Ghiso, J.A., Farías, E.F., Alonso, D.F., Bal de Kier Joffé, E. Int. J. Cancer (1998) [Pubmed]
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