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phb-1  -  Protein PHB-1

Caenorhabditis elegans

 
 
 
 
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High impact information on phb-1

  • Thus, MEC-2, Podocin, and probably many other PHB-domain proteins by binding to themselves, cholesterol, and target proteins regulate the formation and function of large protein-cholesterol supercomplexes in the plasma membrane [1].
  • The prohibitin (PHB)-domain proteins are membrane proteins that regulate a variety of biological activities, including mechanosensation, osmotic homeostasis, and cell signaling, although the mechanism of this regulation is unknown [1].
 

Anatomical context of phb-1

  • This binding requires the PHB domain (including palmitoylation sites within it) and part of the N-terminally adjacent hydrophobic domain that attaches the proteins to the inner leaflet of the plasma membrane [1].

References

  1. Inaugural Article: Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Huber, T.B., Schermer, B., M??ller, R.U., H??hne, M., Bartram, M., Calixto, A., Hagmann, H., Reinhardt, C., Koos, F., Kunzelmann, K., Shirokova, E., Krautwurst, D., Harteneck, C., Simons, M., Pavenst??dt, H., Kerjaschki, D., Thiele, C., Walz, G., Chalfie, M., Benzing, T. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
 
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