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Gene Review

Phb  -  prohibitin

Mus musculus

Synonyms: B-cell receptor-associated protein 32, BAP 32, Prohibitin
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Disease relevance of Phb


High impact information on Phb

  • We show that the CKGGRAKDC peptide associates with prohibitin, a multifunctional membrane protein, and establish prohibitin as a vascular marker of adipose tissue [2].
  • Because prohibitin is also expressed in blood vessels of human white fat, this work may lead to the development of targeted drugs for treatment of obese patients [2].
  • The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein [3].
  • Since prohibitin was identified as an inhibitor of cell proliferation, its association with mIgM, but not mIgD, could explain the different biological events elicited after engagement of each receptor [3].
  • The deduced amino acid sequence of p32 is identical to that of rat prohibitin. p37 is highly homologous to p32 [3].

Biological context of Phb


Anatomical context of Phb

  • A close association of mitochondria with lipid droplets was suggested by the identification of pyruvate carboxylase, prohibitin, and a subunit of ATP synthase in the preparations [6].
  • In addition, differential expression studies of parent and transformed MCF-12F cell lines using microarrays showed that prohibitin mRNA was increased 4-fold in the transformed cells [7].
  • All these proteins were up-regulated in the membranes of H-RasV12-transformed p38alpha-/-cells, except for prohibitin, which was down-regulated [8].

Associations of Phb with chemical compounds


Other interactions of Phb


Analytical, diagnostic and therapeutic context of Phb


  1. Prohibitin: potential role in senescence, development, and tumor suppression. McClung, J.K., Jupe, E.R., Liu, X.T., Dell'Orco, R.T. Exp. Gerontol. (1995) [Pubmed]
  2. Reversal of obesity by targeted ablation of adipose tissue. Kolonin, M.G., Saha, P.K., Chan, L., Pasqualini, R., Arap, W. Nat. Med. (2004) [Pubmed]
  3. The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein. Terashima, M., Kim, K.M., Adachi, T., Nielsen, P.J., Reth, M., Köhler, G., Lamers, M.C. EMBO J. (1994) [Pubmed]
  4. Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence. Coates, P.J., Nenutil, R., McGregor, A., Picksley, S.M., Crouch, D.H., Hall, P.A., Wright, E.G. Exp. Cell Res. (2001) [Pubmed]
  5. Prohibitin attenuates insulin-stimulated glucose and fatty acid oxidation in adipose tissue by inhibition of pyruvate carboxylase. Vessal, M., Mishra, S., Moulik, S., Murphy, L.J. FEBS J. (2006) [Pubmed]
  6. Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. Brasaemle, D.L., Dolios, G., Shapiro, L., Wang, R. J. Biol. Chem. (2004) [Pubmed]
  7. Growth inhibition of carcinogen-transformed MCF-12F breast epithelial cells and hormone-sensitive BT-474 breast cancer cells by 1alpha-hydroxyvitamin D5. Hussain-Hakimjee, E.A., Peng, X., Mehta, R.R., Mehta, R.G. Carcinogenesis (2006) [Pubmed]
  8. Proteomic analysis of p38alpha mitogen-activated protein kinase-regulated changes in membrane fractions of RAS-transformed fibroblasts. Alfonso, P., Dolado, I., Swat, A., Núñez, A., Cuadrado, A., Nebreda, A.R., Casal, J.I. Proteomics (2006) [Pubmed]
  9. Reduction (dethiolation) of protein mixed-disulfides; distribution and specificity of dethiolating enzymes and N,N'-bis(2-chlorethyl)-N-nitrosourea inhibition of an NADPH-dependent cardiac dethiolase. Miller, R.M., Park, E.M., Thomas, J.A. Arch. Biochem. Biophys. (1991) [Pubmed]
  10. Profiling of the secreted proteins during 3T3-L1 adipocyte differentiation leads to the identification of novel adipokines. Wang, P., Mariman, E., Keijer, J., Bouwman, F., Noben, J.P., Robben, J., Renes, J. Cell. Mol. Life Sci. (2004) [Pubmed]
  11. Application of sensitive fluorescent dyes in linkage of laser microdissection and two-dimensional gel electrophoresis as a cancer proteomic study tool. Kondo, T., Seike, M., Mori, Y., Fujii, K., Yamada, T., Hirohashi, S. Proteomics (2003) [Pubmed]
  12. Dissection of melanogenesis with small molecules identifies prohibitin as a regulator. Snyder, J.R., Hall, A., Ni-Komatsu, L., Khersonsky, S.M., Chang, Y.T., Orlow, S.J. Chem. Biol. (2005) [Pubmed]
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