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Gene Review

Phb  -  prohibitin

Rattus norvegicus

Synonyms: Prohibitin
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Disease relevance of Phb


High impact information on Phb


Biological context of Phb


Anatomical context of Phb


Associations of Phb with chemical compounds

  • Prohibitin was immunolocalized in rat ovarian sections probed with antibodies against either proliferating cell nuclear antigen (PCNA) or cholesterol side-chain cleavage cytochrome P450 (P450(scc)) or in terminal deoxynucleotidyl transferase-mediated dUTP nick end labeled sections [4].
  • In addition, strong prohibitin expression was evident in the corpus luteum as well as in follicles undergoing atresia [7].
  • Ethanol gavage significantly increased the relative abundance of prohibitin transcripts at 0.5-2 h post-PH [8].
  • A transient increase in prohibitin transcripts at 0.5-1 h post-PH was found to be characteristic of glucose and nongavaged rats [8].
  • The last two proteins, creatine kinase and prohibitin, increased after chronic restraint stress [9].

Other interactions of Phb

  • Prohibitin and p53 transcripts were increased in relative abundance (as measured by an increase in band intensity) near the G1/S boundary (8-12 h post-PH) following both glucose and ethanol gavage [8].
  • When rat prohibitin tagged with a carboxy-terminal c-Myc epitope was expressed in baby hamster kidney cells the protein was targeted to mitochondria [10].
  • Expressions that decreased to less than half were observed in 20 genes, such as somatostatin and prohibitin, which prohibit cell growth [11].

Analytical, diagnostic and therapeutic context of Phb


  1. cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenz[a]anthracene. Shan, L., He, M., Yu, M., Qiu, C., Lee, N.H., Liu, E.T., Snyderwine, E.G. Carcinogenesis (2002) [Pubmed]
  2. Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells. Nuell, M.J., Stewart, D.A., Walker, L., Friedman, V., Wood, C.M., Owens, G.A., Smith, J.R., Schneider, E.L., Dell' Orco, R., Lumpkin, C.K. Mol. Cell. Biol. (1991) [Pubmed]
  3. Gonadotropin-releasing hormone attenuates pregnancy-associated thymic involution and modulates the expression of antiproliferative gene product prohibitin. Dixit, V.D., Sridaran, R., Edmonsond, M.A., Taub, D., Thompson, W.E. Endocrinology (2003) [Pubmed]
  4. Regulation of prohibitin expression during follicular development and atresia in the mammalian ovary. Thompson, W.E., Asselin, E., Branch, A., Stiles, J.K., Sutovsky, P., Lai, L., Im, G.S., Prather, R.S., Isom, S.C., Rucker, E., Tsang, B.K. Biol. Reprod. (2004) [Pubmed]
  5. Characterization of prohibitin in a newly established rat ovarian granulosa cell line. Thompson, W.E., Branch, A., Whittaker, J.A., Lyn, D., Zilberstein, M., Mayo, K.E., Thomas, K. Endocrinology (2001) [Pubmed]
  6. Expression of prohibitin in rat seminiferous epithelium. Choongkittaworn, N.M., Kim, K.H., Danner, D.B., Griswold, M.D. Biol. Reprod. (1993) [Pubmed]
  7. Immunolocalization and expression of prohibitin, a mitochondrial associated protein within the rat ovaries. Thompson, W.E., Powell, J.M., Whittaker, J.A., Sridaran, R., Thomas, K.H. Anat. Rec. (1999) [Pubmed]
  8. Acute ethanol and selected growth suppressor transcripts in regenerating rat liver. Lumpkin, C.K., Moore, T.L., Tarpley, M.D., Taylor, J.M., Badger, T.M., McClung, J.K. Alcohol (1995) [Pubmed]
  9. Proteomic analysis of mitochondrial proteins in cardiomyocytes from chronic stressed rat. Liu, X.H., Qian, L.J., Gong, J.B., Shen, J., Zhang, X.M., Qian, X.H. Proteomics (2004) [Pubmed]
  10. Prohibitin, an antiproliferative protein, is localized to mitochondria. Ikonen, E., Fiedler, K., Parton, R.G., Simons, K. FEBS Lett. (1995) [Pubmed]
  11. The effect of fructooligosaccharides was analyzed by cDNA expression arrays. Fukushima, A., Ohta, A., Sakai, K., Sakuma, K. J. Nutr. Sci. Vitaminol. (2004) [Pubmed]
  12. Prohibitin expression is decreased in the regenerating liver but not in chemically induced hepatic tumors in rats. Tanno, S., Fukuda, I., Saito, Y., Ogawa, K. Jpn. J. Cancer Res. (1997) [Pubmed]
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