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Gene Review

SFoVgp6  -  orf-2; N-terminus uncertain

Simian foamy virus

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Disease relevance of SFoVgp6

  • The human foamy virus internal promoter directs the expression of the functional Bel 1 transactivator and Bet protein early after infection [1].
  • This phenomenon is independent of HIV-1 receptor, CD4, and it is not related to PFV-1 Bet protein expression [2].
  • While inhibition of PFV virion infectivity by primate APOBEC3 proteins was largely relieved by coexpression of the PFV Bet protein, a cytoplasmic auxiliary protein of previously uncertain function, Bet failed to relieve inhibition caused by murine APOBEC3 [3].
  • We suggest that inhibition of provirus integration by Bet protein may serve a distinct function in the unique foamy virus replication cycle [4].

High impact information on SFoVgp6


Analytical, diagnostic and therapeutic context of SFoVgp6

  • In cell cultures, these FFV-FCV vectors efficiently transduced and expressed a hybrid fusion protein consisting of the essential FFV Bet protein and the attached FCV E domains [7].
  • Analysis of HFV expression in Dami-Cl cells, by Northern blot and immunoprecipitation, shows that the most striking difference between cytolytic and persistent HFV infection was the lack of expression of structural viral proteins, in contrast with Bet protein expression, which is maintained [8].


  1. The human foamy virus internal promoter directs the expression of the functional Bel 1 transactivator and Bet protein early after infection. Löchelt, M., Flügel, R.M., Aboud, M. J. Virol. (1994) [Pubmed]
  2. Persistent infection with primate foamy virus type 1 increases human immunodeficiency virus type 1 cell binding via a Bet-independent mechanism. Schiffer, C., Lecellier, C.H., Mannioui, A., Felix, N., Nelson, E., Lehmann-Che, J., Giron, M.L., Gluckman, J.C., Saib, A., Canque, B. J. Virol. (2004) [Pubmed]
  3. Foamy virus Bet proteins function as novel inhibitors of the APOBEC3 family of innate antiretroviral defense factors. Russell, R.A., Wiegand, H.L., Moore, M.D., Schäfer, A., McClure, M.O., Cullen, B.R. J. Virol. (2005) [Pubmed]
  4. Cells expressing the human foamy virus (HFV) accessory Bet protein are resistant to productive HFV superinfection. Bock, M., Heinkelein, M., Lindemann, D., Rethwilm, A. Virology (1998) [Pubmed]
  5. The antiretroviral activity of APOBEC3 is inhibited by the foamy virus accessory Bet protein. Löchelt, M., Romen, F., Bastone, P., Muckenfuss, H., Kirchner, N., Kim, Y.B., Truyen, U., Rösler, U., Battenberg, M., Saib, A., Flory, E., Cichutek, K., Münk, C. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  6. Intra- and intercellular trafficking of the foamy virus auxiliary bet protein. Lecellier, C.H., Vermeulen, W., Bachelerie, F., Giron, M.L., Saïb, A. J. Virol. (2002) [Pubmed]
  7. Application of chimeric feline foamy virus-based retroviral vectors for the induction of antiviral immunity in cats. Schwantes, A., Truyen, U., Weikel, J., Weiss, C., Löchelt, M. J. Virol. (2003) [Pubmed]
  8. Human foamy virus DNA forms and expression in persistently infected Dami megakaryocytic cells. Wybier-Franqui, J., Tobaly-Tapiero, J., Coronel, A., Giron, M.L., Chopin-Robert, C., Peries, J., Emanoil-Ravier, R. AIDS Res. Hum. Retroviruses (1995) [Pubmed]
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