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Gene Review:

Mef2a - myocyte enhancer factor 2A

Mus musculus

Synonyms: A430079H05Rik, Myocyte-specific enhancer factor 2A

Naya, F.J. et al., Ghosh-Choudhury, N. et al.

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Disease relevance of Mef2a

The few Mef2a(-/-) mice that survived to adulthood also showed a deficiency of cardiac mitochondria and susceptibility to sudden death [1].

High impact information on Mef2a

Paradoxically, MEF2 transcriptional activity, revealed by the expression of a MEF2-dependent transgene, was enhanced in the hearts of Mef2a-mutant mice, reflecting the transcriptional activation of residual MEF2D [1].
Most mice lacking Mef2a died suddenly within the first week of life and exhibited pronounced dilation of the right ventricle, myofibrillar fragmentation, mitochondrial disorganization and activation of a fetal cardiac gene program [1].
Phosphatidylinositol 3-kinase regulates bone morphogenetic protein-2 (BMP-2)-induced myocyte enhancer factor 2A-dependent transcription of BMP-2 gene in cardiomyocyte precursor cells [2].

References

Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor. Naya, F.J., Black, B.L., Wu, H., Bassel-Duby, R., Richardson, J.A., Hill, J.A., Olson, E.N. Nat. Med. (2002) [Pubmed]
Phosphatidylinositol 3-kinase regulates bone morphogenetic protein-2 (BMP-2)-induced myocyte enhancer factor 2A-dependent transcription of BMP-2 gene in cardiomyocyte precursor cells. Ghosh-Choudhury, N., Abboud, S.L., Mahimainathan, L., Chandrasekar, B., Choudhury, G.G. J. Biol. Chem. (2003) [Pubmed]

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