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Gene Review:

cep-1 - Protein CEP-1

Caenorhabditis elegans

Derry, W.B. et al., Schumacher, B. et al., Schumacher, B. et al., Schumacher, B. et al., Quevedo, C. et al.

Schumacher, Gartner, Derry, Putzke, Rothman,

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Disease relevance of cep-1

Moreover, although somatic apoptosis is unaffected, cep-1 mutants show hypersensitivity to hypoxia-induced lethality and decreased longevity in response to starvation-induced stress [1].

High impact information on cep-1

This study reveals that the regulation of cep-1/p53 translation influences DNA damage-induced apoptosis and demonstrates the physiological importance of this mechanism [2].
The gene encoding this protein, cep-1, promotes DNA damage-induced apoptosis and is required for normal meiotic chromosome segregation in the germ line [1].
We show that ced-13 mRNA accumulates following DNA damage, and that this accumulation is dependent on an intact C. elegans cep-1/p53 gene [3].
The antiapoptotic activity of akt-1 is independent of its target gene daf-16 but dependent on cep-1/p53 [4].
The authors have recently reported a novel mechanism of C. elegans cep-1/p53 regulation through germ line defective-1-mediated translational repression [5].

References

Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance. Derry, W.B., Putzke, A.P., Rothman, J.H. Science (2001) [Pubmed]
Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis. Schumacher, B., Hanazawa, M., Lee, M.H., Nayak, S., Volkmann, K., Hofmann, E.R., Hofmann, R., Hengartner, M., Schedl, T., Gartner, A. Cell (2005) [Pubmed]
C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage. Schumacher, B., Schertel, C., Wittenburg, N., Tuck, S., Mitani, S., Gartner, A., Conradt, B., Shaham, S. Cell Death Differ. (2005) [Pubmed]
AKT-1 Regulates DNA-Damage-Induced Germline Apoptosis in C. elegans. Quevedo, C., Kaplan, D.R., Derry, W.B. Curr. Biol. (2007) [Pubmed]
Translational regulation of p53 as a potential tumor therapy target. Schumacher, B., Gartner, A. Future oncology (London) (2006) [Pubmed]

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