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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, p53

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Disease relevance of Genes, p53


High impact information on Genes, p53

  • IMPLICATIONS: The possible interaction of chronic HBV infection and p53 gene mutation, suggested by these data, indicates a mechanism by which HBV infection beginning early in life could contribute to the subsequent development of HCC [6].
  • The chimeric (p53(KI)) allele thus appears to provide a biological equivalent to the endogenous murine (p53(+)) gene [7].
  • Ribozyme derivatives that combine a mutation which indirectly slows down the rate of the chemical cleavage step by weakening guanosine binding with additional mutations that weaken substrate binding have greatly enhanced specificity with short oligonucleotide substrates and an mRNA fragment derived from the p53 gene [8].
  • Cell death was preceded by dose-dependent increase in p21(WAF1/CIP1) expression, without apparent stabilisation of the TP53 gene product [9].
  • However, it is uncertain whether p53 overexpression really reflects p53 gene mutation or loss of p53 function. p21WAF1, an inhibitor of cyclin-dependent kinases, is activated by wild-type p53 protein, not by mutant type [10].

Biological context of Genes, p53

  • Furthermore, PADPRP inhibitors potentiated apoptosis induced by TZM in Jurkat cells, which possess a mutated p53 gene and are tolerant to O6-methylguanine adducts [11].
  • Following amplification of exons 5 to 8 of the p53 gene by means of the polymerase chain reaction technique, single-strand conformation polymorphism analysis disclosed an anomalous migration pattern in 23 of the 39 p53+ tumors and in four of the 35 p53- tumors analyzed [12].
  • We studied the correlation between the morphology of the lesions; their clonality based on immunoglobulin (Ig) heavy chain gene rearrangement analysis and immunohistochemistry; their proliferative activity as measured by immunoperoxidase staining for the proliferating cell nuclear antigen (PCNA) and the presence of p53 gene product overexpression [13].
  • Initially described as an oncogene, at the end of the 1980s, the wild-type p53 gene (TP53) was later shown to be capable of suppressing the proliferation of transformed cells [14].
  • Locally, luteal cytokines may be involved in the up-regulation of NOS activity, while downstream NO may inhibit steroroidogenesis and induce expression of p53 gene after removal of the protective action of progesterone [15].
  • Stabilization and activation of p53 are regulated independently by different phosphorylation events [16].

Associations of Genes, p53 with chemical compounds

  • Phenol-chloroform-extracted DNA specimens were employed for the detection of HBV infection and p53 gene mutations [17].
  • Effects of endocrine disrupting chemicals on distinct expression patterns of estrogen receptor, cytochrome P450 aromatase and p53 genes in oryzias latipes liver [18].

Gene context of Genes, p53

  • By contrast, a 34-bp deletion in exon 7 of the TP53 (p53) gene was detected [19].
  • In 8 of the 9 tumors, mutation of p53 gene or overexpression of MDM2, or both, was detected [20].
  • This blockage was noted as a decrease in the level of amplification of the fragments of a transcribed gene (beta-actin), an inducible gene (p53), and a nontranscribed one (IgE, heavy chain) [21].



  1. p21WAF1/CIP1 and MDM2 expression in non-Hodgkin's lymphoma and their relationship to p53 status: a p53+, MDM2-, p21-immunophenotype associated with missense p53 mutations. Villuendas, R., Pezzella, F., Gatter, K., Algara, P., Sánchez-Beato, M., Martínez, P., Martínez, J.C., Muñoz, K., García, P., Sánchez, L., Kocialkowsky, S., Campo, E., Orradre, J.L., Piris, M.A. J. Pathol. (1997) [Pubmed]
  2. Defective nucleotide excision repair in xpc mutant mice and its association with cancer predisposition. Friedberg, E.C., Bond, J.P., Burns, D.K., Cheo, D.L., Greenblatt, M.S., Meira, L.B., Nahari, D., Reis, A.M. Mutat. Res. (2000) [Pubmed]
  3. Differential activation of the Fas/CD95 pathway by Ad-p53 in human gliomas. Cerrato, J.A., Khan, T., Koul, D., Lang, F.F., Conrad, C.A., Yung, W.K., Liu, T.J. Int. J. Oncol. (2004) [Pubmed]
  4. Pilocytic astrocytoma presenting as primary diffuse leptomeningeal gliomatosis: report of a unique case and review of the literature. Bohner, G., Masuhr, F., Distl, R., Katchanov, J., Klingebiel, R., Zschenderlein, R., von Deimling, A., van Landeghem, F.K. Acta Neuropathol. (2005) [Pubmed]
  5. Genetics of tumors of the head and neck. Knudson, A. Arch. Otolaryngol. Head Neck Surg. (1993) [Pubmed]
  6. Mutations of p53 gene in hepatocellular carcinoma: roles of hepatitis B virus and aflatoxin contamination in the diet. Hsia, C.C., Kleiner, D.E., Axiotis, C.A., Di Bisceglie, A., Nomura, A.M., Stemmermann, G.N., Tabor, E. J. Natl. Cancer Inst. (1992) [Pubmed]
  7. Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool. Luo, J.L., Yang, Q., Tong, W.M., Hergenhahn, M., Wang, Z.Q., Hollstein, M. Oncogene (2001) [Pubmed]
  8. Optimizing the substrate specificity of a group I intron ribozyme. Zarrinkar, P.P., Sullenger, B.A. Biochemistry (1999) [Pubmed]
  9. Study of in vitro and in vivo effects of the piperidine nitroxide Tempol--a potential new therapeutic agent for gliomas. Gariboldi, M.B., Ravizza, R., Petterino, C., Castagnaro, M., Finocchiaro, G., Monti, E. Eur. J. Cancer (2003) [Pubmed]
  10. Immunohistochemical study of p21WAF1 and p53 proteins in prostatic cancer and their prognostic significance. Matsushima, H., Sasaki, T., Goto, T., Hosaka, Y., Homma, Y., Kitamura, T., Kawabe, K., Sakamoto, A., Murakami, T., Machinami, R. Hum. Pathol. (1998) [Pubmed]
  11. Role of wild-type p53 on the antineoplastic activity of temozolomide alone or combined with inhibitors of poly(ADP-ribose) polymerase. Tentori, L., Lacal, P.M., Benincasa, E., Franco, D., Faraoni, I., Bonmassar, E., Graziani, G. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
  12. Association of p53 gene and protein alterations with metastases in colorectal cancer. Bertorelle, R., Esposito, G., Del Mistro, A., Belluco, C., Nitti, D., Lise, M., Chieco-Bianchi, L. Am. J. Surg. Pathol. (1995) [Pubmed]
  13. Posttransplantation lymphoproliferative disorders in bone marrow transplant recipients are aggressive diseases with a high incidence of adverse histologic and immunobiologic features. Orazi, A., Hromas, R.A., Neiman, R.S., Greiner, T.C., Lee, C.H., Rubin, L., Haskins, S., Heerema, N.A., Gharpure, V., Abonour, R., Srour, E.F., Cornetta, K. Am. J. Clin. Pathol. (1997) [Pubmed]
  14. p53: prospects for cancer gene therapy. Soddu, S., Sacchi, A. Cytokines Cell. Mol. Ther. (1998) [Pubmed]
  15. Expression patterns of cytokines, p53 and nitric oxide synthase isoenzymes in corpora lutea of pseudopregnant rabbits during spontaneous luteolysis. Boiti, C., Guelfi, G., Zerani, M., Zampini, D., Brecchia, G., Gobbetti, A. Reproduction (2004) [Pubmed]
  16. Stabilization and activation of p53 are regulated independently by different phosphorylation events. Chernov, M.V., Ramana, C.V., Adler, V.V., Stark, G.R. Proc. Natl. Acad. Sci. U. S. A. (1998) [Pubmed]
  17. P53 tumor suppressor gene mutations in hepatocellular carcinoma patients in India. Katiyar, S., Dash, B.C., Thakur, V., Guptan, R.C., Sarin, S.K., Das, B.C. Cancer (2000) [Pubmed]
  18. Effects of endocrine disrupting chemicals on distinct expression patterns of estrogen receptor, cytochrome P450 aromatase and p53 genes in oryzias latipes liver. Min, J., Lee, S.K., Gu, M.B. J. Biochem. Mol. Toxicol. (2003) [Pubmed]
  19. A case of lymphoblastoid natural killer (NK)-cell lymphoma: association with the NK-cell receptor complex CD94/NKG2 and TP53 intragenic deletion. Knudsen, H., Grønbaek, K., thor Straten, P., Gisselø, C., Johansen, P., Timshel, S., Bergmann, O.J., Hansen, N.E., Ralfkiaer, E. Br. J. Dermatol. (2002) [Pubmed]
  20. Results of hyperamplification of centrosomes in naturally developing tumors of dogs. Setoguchi, A., Okuda, M., Nishida, E., Yazawa, M., Ishizaka, T., Hong, S.H., Hisasue, M., Nishimura, R., Sasaki, N., Yoshikawa, Y., Masuda, K., Ohno, K., Tsujimoto, H. Am. J. Vet. Res. (2001) [Pubmed]
  21. Estimation of DNA damage and repair in tissues of gamma-irradiated animals using the polymerase chain reaction. Ploskonosova, I.I., Baranov, V.I., Gaziev, A.I. Biochemistry Mosc. (1999) [Pubmed]
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