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Gene Review

fer-1  -  Protein FER-1

Caenorhabditis elegans

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Disease relevance of fer-1


High impact information on fer-1


Biological context of fer-1

  • We identified the mutations associated with five fer-1 alleles, all of which are missense mutations causing single amino acid changes [6].

Anatomical context of fer-1

  • Mutations in the gene fer-1 cause abnormal spermatozoa in which the MOs do not fuse, although they abut the plasma membrane normally [6].
  • Here we describe the fer-1 gene, which we found to be approximately 8.6 kb in length and to encode a 6.2 kb transcript whose expression is limited to the primary spermatocytes, the cells in which the MOs form. fer-1 is predicted to encode a 235 kDa protein which is highly charged except for a putative transmembrane domain near the C terminus [6].

Associations of fer-1 with chemical compounds

  • Most of the fer-1 mutations fall within these C2 domains, showing that they have distinct, non-redundant functions [5].


  1. A gene related to Caenorhabditis elegans spermatogenesis factor fer-1 is mutated in limb-girdle muscular dystrophy type 2B. Bashir, R., Britton, S., Strachan, T., Keers, S., Vafiadaki, E., Lako, M., Richard, I., Marchand, S., Bourg, N., Argov, Z., Sadeh, M., Mahjneh, I., Marconi, G., Passos-Bueno, M.R., Moreira, E.d.e. .S., Zatz, M., Beckmann, J.S., Bushby, K. Nat. Genet. (1998) [Pubmed]
  2. Defective membrane repair in dysferlin-deficient muscular dystrophy. Bansal, D., Miyake, K., Vogel, S.S., Groh, S., Chen, C.C., Williamson, R., McNeil, P.L., Campbell, K.P. Nature (2003) [Pubmed]
  3. Sperm morphogenesis in wild-type and fertilization-defective mutants of Caenorhabditis elegans. Ward, S., Argon, Y., Nelson, G.A. J. Cell Biol. (1981) [Pubmed]
  4. Myoferlin, a candidate gene and potential modifier of muscular dystrophy. Davis, D.B., Delmonte, A.J., Ly, C.T., McNally, E.M. Hum. Mol. Genet. (2000) [Pubmed]
  5. FER-1 regulates Ca2+ -mediated membrane fusion during C. elegans spermatogenesis. Washington, N.L., Ward, S. J. Cell. Sci. (2006) [Pubmed]
  6. A nematode gene required for sperm vesicle fusion. Achanzar, W.E., Ward, S. J. Cell. Sci. (1997) [Pubmed]
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