Gene Review:
mag-1 - Protein MAG-1
Caenorhabditis elegans
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High impact information on mag-1
- These results suggest that mag-1 interacts with the fog, fem, and gld genes and acts independently of her-1 [1].
- We show here that mag-1(RNAi) causes masculinization of the germ line (Mog phenotype) in RNA-injected hermaphrodites, suggesting that mag-1 is involved in hermaphrodite germ-line sex determination [1].
- We propose that mag-1 normally allows oogenesis by inhibiting function of one or more of these masculinizing genes, which act during the fourth larval stage to promote transient sperm production in the hermaphrodite germ line [1].
- The temporal expression pattern of the mag-1 gene prior to and during morphogenesis appears to be consistent with an essential role of mag-1 in embryonic hypodermal organization and elongation [1].
Biological context of mag-1
- When the Mog phenotype is suppressed by a fog-2(lf) mutation, mag-1(RNAi) also causes lethality in the progeny embryos of RNA-injected, mated hermaphrodites, suggesting an essential role for mag-1 during embryogenesis [1].
References
- mag-1, a homolog of Drosophila mago nashi, regulates hermaphrodite germ-line sex determination in Caenorhabditis elegans. Li, W., Boswell, R., Wood, W.B. Dev. Biol. (2000) [Pubmed]
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