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Gene Review

hda-3  -  Protein HDA-3

Caenorhabditis elegans

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Disease relevance of hda-3

  • Generally, knockdown of individual C. elegans HDACs enhanced Htn-Q150 toxicity, but knockdown of C. elegans hda-3 suppressed toxicity [1].

High impact information on hda-3

  • Our results identify KIN-29 as a new regulator of MEF2/HDAC functions in the nervous system, reveal cell-specific mechanisms of action of this pathway in vivo and demonstrate remarkable complexity in the regulation of CR gene expression in C. elegans [2].
  • Neuronal expression of hda-3 restored Htn-Q150 toxicity and suggested that C. elegans HDAC3 (HDA-3) acts within neurons to promote degeneration in response to Htn-Q150 [1].


  1. Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity. Bates, E.A., Victor, M., Jones, A.K., Shi, Y., Hart, A.C. J. Neurosci. (2006) [Pubmed]
  2. KIN-29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC. van der Linden, A.M., Nolan, K.M., Sengupta, P. EMBO J. (2007) [Pubmed]
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