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Gene Review

Hdac1  -  histone deacetylase 1

Mus musculus

Synonyms: HD1, Hdac1-ps, Histone deacetylase 1, MommeD5, RPD3
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Disease relevance of Hdac1

  • We investigated the role of a histone deacetylase (HDAC)-dependent mechanism in the transcriptional repression of cx43 in a panel of prostate cancer cells [1].
  • In contrast the HDAC1 gene in other mouse strains such as C57B16, C3H/An and C-RY lacks the retrovirus [2].
  • In the genome of 129SV mice the largest intervening sequence of the HDAC1 gene, intron 3, harbors a complete copy of the endogenous retrovirus MuERV-L [2].
  • Recently, the inhibition of histone deacetylase (HDAC) enzymes has attracted attention in the oncologic community as a new therapeutic opportunity for hematologic and solid tumors including non-small cell lung cancer (NSCLC) [3].
  • Histone deacetylase (HDAC) inhibitors alleviate neurological phenotypes in fly and mouse models of polyQ disease, although the therapeutic effect is limited by the toxicity of these compounds [4].

Psychiatry related information on Hdac1


High impact information on Hdac1

  • We show that m-Bop is a histone deacetylase-dependent transcriptional repressor [8].
  • NoRC mediates rDNA silencing by recruiting DNA methyltransferase and histone deacetylase activity to the rDNA promoter, thus establishing structural characteristics of heterochromatin such as DNA methylation, histone hypoacetylation and methylation of the Lys9 residue of histone H3 [9].
  • We suggest that the process of DNA methylation, mediated by Dnmt1, may depend on or generate an altered chromatin state via histone deacetylase activity [10].
  • Using specific antibodies, however, we find here that MBD2 in HeLa cells is associated with histone deacetylase (HDAC) in the MeCP1 repressor complex [11].
  • These two proteins locally influence chromatin structure: Rb recruits a histone deacetylase, whereas CBP is a histone acetyltransferase [12].

Chemical compound and disease context of Hdac1


Biological context of Hdac1


Anatomical context of Hdac1


Associations of Hdac1 with chemical compounds


Physical interactions of Hdac1


Regulatory relationships of Hdac1


Other interactions of Hdac1


Analytical, diagnostic and therapeutic context of Hdac1


  1. A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells. Hernandez, M., Shao, Q., Yang, X.J., Luh, S.P., Kandouz, M., Batist, G., Laird, D.W., Alaoui-Jamali, M.A. Prostate (2006) [Pubmed]
  2. Molecular cloning and characterization of the mouse histone deacetylase 1 gene: integration of a retrovirus in 129SV mice. Khier, H., Bartl, S., Schuettengruber, B., Seiser, C. Biochim. Biophys. Acta (1999) [Pubmed]
  3. Histone deacetylase inhibitors suppress the inducibility of nuclear factor-kappaB by tumor necrosis factor-alpha receptor-1 down-regulation. Imre, G., Gekeler, V., Leja, A., Beckers, T., Boehm, M. Cancer Res. (2006) [Pubmed]
  4. Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy. Minamiyama, M., Katsuno, M., Adachi, H., Waza, M., Sang, C., Kobayashi, Y., Tanaka, F., Doyu, M., Inukai, A., Sobue, G. Hum. Mol. Genet. (2004) [Pubmed]
  5. Regulation of CRE-dependent transcription by presenilins: prospects for therapy of Alzheimer's disease. Beglopoulos, V., Shen, J. Trends Pharmacol. Sci. (2006) [Pubmed]
  6. Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease. Hockly, E., Richon, V.M., Woodman, B., Smith, D.L., Zhou, X., Rosa, E., Sathasivam, K., Ghazi-Noori, S., Mahal, A., Lowden, P.A., Steffan, J.S., Marsh, J.L., Thompson, L.M., Lewis, C.M., Marks, P.A., Bates, G.P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  7. The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases. Simonini, M.V., Camargo, L.M., Dong, E., Maloku, E., Veldic, M., Costa, E., Guidotti, A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  8. Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Gottlieb, P.D., Pierce, S.A., Sims, R.J., Yamagishi, H., Weihe, E.K., Harriss, J.V., Maika, S.D., Kuziel, W.A., King, H.L., Olson, E.N., Nakagawa, O., Srivastava, D. Nat. Genet. (2002) [Pubmed]
  9. The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. Santoro, R., Li, J., Grummt, I. Nat. Genet. (2002) [Pubmed]
  10. DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Fuks, F., Burgers, W.A., Brehm, A., Hughes-Davies, L., Kouzarides, T. Nat. Genet. (2000) [Pubmed]
  11. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Ng, H.H., Zhang, Y., Hendrich, B., Johnson, C.A., Turner, B.M., Erdjument-Bromage, H., Tempst, P., Reinberg, D., Bird, A. Nat. Genet. (1999) [Pubmed]
  12. Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A. Ait-Si-Ali, S., Ramirez, S., Barre, F.X., Dkhissi, F., Magnaghi-Jaulin, L., Girault, J.A., Robin, P., Knibiehler, M., Pritchard, L.L., Ducommun, B., Trouche, D., Harel-Bellan, A. Nature (1998) [Pubmed]
  13. Antitumor effects of a novel phenylbutyrate-based histone deacetylase inhibitor, (S)-HDAC-42, in prostate cancer. Kulp, S.K., Chen, C.S., Wang, D.S., Chen, C.Y., Chen, C.S. Clin. Cancer Res. (2006) [Pubmed]
  14. Effects of histone deacetylase inhibitors on estradiol-induced proliferation and hyperplasia formation in the mouse uterus. Gunin, A.G., Kapitova, I.N., Suslonova, N.V. J. Endocrinol. (2005) [Pubmed]
  15. Sodium butyrate and tributyrin induce in vivo growth inhibition and apoptosis in human prostate cancer. Kuefer, R., Hofer, M.D., Altug, V., Zorn, C., Genze, F., Kunzi-Rapp, K., Hautmann, R.E., Gschwend, J.E. Br. J. Cancer (2004) [Pubmed]
  16. A histone deacetylase inhibitor potentiates retinoid receptor action in embryonal carcinoma cells. Minucci, S., Horn, V., Bhattacharyya, N., Russanova, V., Ogryzko, V.V., Gabriele, L., Howard, B.H., Ozato, K. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  17. Histone deacetylase inhibitors reduce polyglutamine toxicity. McCampbell, A., Taye, A.A., Whitty, L., Penney, E., Steffan, J.S., Fischbeck, K.H. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  18. Inefficient reprogramming of the hematopoietic stem cell genome following nuclear transfer. Inoue, K., Ogonuki, N., Miki, H., Hirose, M., Noda, S., Kim, J.M., Aoki, F., Miyoshi, H., Ogura, A. J. Cell. Sci. (2006) [Pubmed]
  19. Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. Kurtev, V., Margueron, R., Kroboth, K., Ogris, E., Cavailles, V., Seiser, C. J. Biol. Chem. (2004) [Pubmed]
  20. Both Sp1 and Sp3 are responsible for p21waf1 promoter activity induced by histone deacetylase inhibitor in NIH3T3 cells. Xiao, H., Hasegawa, T., Isobe, K. J. Cell. Biochem. (1999) [Pubmed]
  21. Trichostatin A, an inhibitor of histone deacetylase, inhibits smooth muscle cell proliferation via induction of p21(WAF1). Okamoto, H., Fujioka, Y., Takahashi, A., Takahashi, T., Taniguchi, T., Ishikawa, Y., Yokoyama, M. J. Atheroscler. Thromb. (2006) [Pubmed]
  22. Hepatic differentiation and transcriptional profile of the mouse liver epithelial progenitor cells (LEPCs) under the induction of sodium butyrate. Li, W., You, P., Wei, Q., Li, Y., Fu, X., Ding, X., Wang, X., Hu, Y. Front. Biosci. (2007) [Pubmed]
  23. LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression. Aung, H.T., Schroder, K., Himes, S.R., Brion, K., van Zuylen, W., Trieu, A., Suzuki, H., Hayashizaki, Y., Hume, D.A., Sweet, M.J., Ravasi, T. FASEB J. (2006) [Pubmed]
  24. The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. Fajas, L., Egler, V., Reiter, R., Hansen, J., Kristiansen, K., Debril, M.B., Miard, S., Auwerx, J. Dev. Cell (2002) [Pubmed]
  25. Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure. Ghoshal, K., Datta, J., Majumder, S., Bai, S., Dong, X., Parthun, M., Jacob, S.T. Mol. Cell. Biol. (2002) [Pubmed]
  26. Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor. Nomura, T., Khan, M.M., Kaul, S.C., Dong, H.D., Wadhwa, R., Colmenares, C., Kohno, I., Ishii, S. Genes Dev. (1999) [Pubmed]
  27. Combined effects of novel tyrosine kinase inhibitor AMN107 and histone deacetylase inhibitor LBH589 against Bcr-Abl-expressing human leukemia cells. Fiskus, W., Pranpat, M., Bali, P., Balasis, M., Kumaraswamy, S., Boyapalle, S., Rocha, K., Wu, J., Giles, F., Manley, P.W., Atadja, P., Bhalla, K. Blood (2006) [Pubmed]
  28. Apo2l/Tumor necrosis factor-related apoptosis-inducing ligand prevents breast cancer-induced bone destruction in a mouse model. Thai, l.e. .M., Labrinidis, A., Hay, S., Liapis, V., Bouralexis, S., Welldon, K., Coventry, B.J., Findlay, D.M., Evdokiou, A. Cancer Res. (2006) [Pubmed]
  29. Association of the mSin3A-histone deacetylase 1/2 corepressor complex with the mouse steroidogenic acute regulatory protein gene. Clem, B.F., Clark, B.J. Mol. Endocrinol. (2006) [Pubmed]
  30. Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Guan, H.P., Ishizuka, T., Chui, P.C., Lehrke, M., Lazar, M.A. Genes Dev. (2005) [Pubmed]
  31. The COOH-terminal region of pRb2/p130 binds to histone deacetylase 1 (HDAC1), enhancing transcriptional repression of the E2F-dependent cyclin A promoter. Stiegler, P., De Luca, A., Bagella, L., Giordano, A. Cancer Res. (1998) [Pubmed]
  32. Suppression of adiponectin gene expression by histone deacetylase inhibitor valproic acid. Qiao, L., Schaack, J., Shao, J. Endocrinology (2006) [Pubmed]
  33. Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms. Sun, H., Taneja, R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  34. Histone deacetylase inhibitors promote osteoblast maturation. Schroeder, T.M., Westendorf, J.J. J. Bone Miner. Res. (2005) [Pubmed]
  35. Identification of mouse histone deacetylase 1 as a growth factor-inducible gene. Bartl, S., Taplick, J., Lagger, G., Khier, H., Kuchler, K., Seiser, C. Mol. Cell. Biol. (1997) [Pubmed]
  36. Cloning and characterization of the mouse histone deacetylase-2 gene. Zeng, Y., Tang, C.M., Yao, Y.L., Yang, W.M., Seto, E. J. Biol. Chem. (1998) [Pubmed]
  37. TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3. Wang, L., Hiebert, S.W. Oncogene (2001) [Pubmed]
  38. Trichostatin A-induced detransformation correlates with decreased focal adhesion kinase phosphorylation at tyrosine 861 in ras-transformed fibroblasts. Lim, Y., Han, I., Kwon, H.J., Oh, E.S. J. Biol. Chem. (2002) [Pubmed]
  39. Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Haggarty, S.J., Koeller, K.M., Wong, J.C., Grozinger, C.M., Schreiber, S.L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  40. Histone deacetylase inhibitors stimulate mitochondrial HMG-CoA synthase gene expression via a promoter proximal Sp1 site. Camarero, N., Nadal, A., Barrero, M.J., Haro, D., Marrero, P.F. Nucleic Acids Res. (2003) [Pubmed]
  41. In vivo biological activity of the histone deacetylase inhibitor LAQ824 is detectable with 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography. Leyton, J., Alao, J.P., Da Costa, M., Stavropoulou, A.V., Latigo, J.R., Perumal, M., Pillai, R., He, Q., Atadja, P., Lam, E.W., Workman, P., Vigushin, D.M., Aboagye, E.O. Cancer Res. (2006) [Pubmed]
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