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Gene Review

HDAC1  -  histone deacetylase 1

Gallus gallus

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Disease relevance of HDAC1


High impact information on HDAC1


Biological context of HDAC1


Anatomical context of HDAC1


Associations of HDAC1 with chemical compounds

  • Treatment with trichostatin A reduced the HDAC activities in immunoprecipitates obtained with anti-chHDAC-1 and -2 antisera [13].
  • Treatment of the nuclear matrix with 1.6 M NaCl and 1% 2-mercaptoethanol solubilized histone deacetylase which chromatographed as 400 and 220 kDa forms on a Superdex 200 column [14].
  • Protein restriction consistently, but differentially, enhanced maximal ACTH-induced corticosterone production by the subpopulations: values of LDAC-1, -2, and -3 and HDAC from protein restricted birds were, respectively, 116, 43, 33, and 20% greater than those of corresponding cell subpopulations from control birds [15].

Regulatory relationships of HDAC1


Other interactions of HDAC1


Analytical, diagnostic and therapeutic context of HDAC1


  1. Rapid induction of histone hyperacetylation and cellular differentiation in human breast tumor cell lines following degradation of histone deacetylase-1. Zhou, Q., Melkoumian, Z.K., Lucktong, A., Moniwa, M., Davie, J.R., Strobl, J.S. J. Biol. Chem. (2000) [Pubmed]
  2. Avian erythroleukemia: a model for corepressor function in cancer. Rietveld, L.E., Caldenhoven, E., Stunnenberg, H.G. Oncogene (2001) [Pubmed]
  3. Nuclear distribution of histone deacetylase: a marker enzyme for the internal nuclear matrix. Hendzel, M.J., Davie, J.R. Biochim. Biophys. Acta (1992) [Pubmed]
  4. Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators. Pikaart, M.J., Recillas-Targa, F., Felsenfeld, G. Genes Dev. (1998) [Pubmed]
  5. Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum. Brosch, G., Ransom, R., Lechner, T., Walton, J.D., Loidl, P. Plant Cell (1995) [Pubmed]
  6. Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytes. Matthews, S.A., Liu, P., Spitaler, M., Olson, E.N., McKinsey, T.A., Cantrell, D.A., Scharenberg, A.M. Mol. Cell. Biol. (2006) [Pubmed]
  7. Purification and characterization of chicken erythrocyte histone deacetylase 1. Sun, J.M., Chen, H.Y., Moniwa, M., Samuel, S., Davie, J.R. Biochemistry (1999) [Pubmed]
  8. Histone acetylation in Zea mays. II. Biological significance of post-translational histone acetylation during embryo germination. Georgieva, E.I., López-Rodas, G., Sendra, R., Gröbner, P., Loidl, P. J. Biol. Chem. (1991) [Pubmed]
  9. Subcellular location of enzymes involved in core histone acetylation. Grabher, A., Brosch, G., Sendra, R., Lechner, T., Eberharter, A., Georgieva, E.I., López-Rodas, G., Franco, L., Dietrich, H., Loidl, P. Biochemistry (1994) [Pubmed]
  10. A comparative study of histone deacetylases of plant, fungal and vertebrate cells. Lechner, T., Lusser, A., Brosch, G., Eberharter, A., Goralik-Schramel, M., Loidl, P. Biochim. Biophys. Acta (1996) [Pubmed]
  11. Effect of high mobility group nonhistone proteins HMG-20 (ubiquitin) and HMG-17 on histone deacetylase activity assayed in vitro. Mezquita, J., Chiva, M., Vidal, S., Mezquita, C. Nucleic Acids Res. (1982) [Pubmed]
  12. Measurement of histone acetyltransferase and histone deacetylase activities and kinetics of histone acetylation. Sun, J.M., Spencer, V.A., Chen, H.Y., Li, L., Davie, J.R. Methods (2003) [Pubmed]
  13. Chicken histone deacetylase-2 controls the amount of the IgM H-chain at the steps of both transcription of its gene and alternative processing of its pre-mRNA in the DT40 cell line. Takami, Y., Kikuchi, H., Nakayama, T. J. Biol. Chem. (1999) [Pubmed]
  14. Properties of chicken erythrocyte histone deacetylase associated with the nuclear matrix. Li, W., Chen, H.Y., Davie, J.R. Biochem. J. (1996) [Pubmed]
  15. Dietary protein restriction stress in the domestic chicken (Gallus gallus domesticus) induces remodeling of adrenal steroidogenic tissue that supports hyperfunction. Carsia, R.V., Weber, H. Gen. Comp. Endocrinol. (2000) [Pubmed]
  16. WD dipeptide motifs and LXXLL motif of chicken HIRA are essential for interactions with the p48 subunit of chromatin assembly factor-1 and histone deacetylase-2 in vitro and in vivo. Ahmad, A., Takami, Y., Nakayama, T. Gene (2004) [Pubmed]
  17. Developmental changes in transcription factors associated with the nuclear matrix of chicken erythrocytes. Sun, J.M., Chen, H.Y., Litchfield, D.W., Davie, J.R. J. Cell. Biochem. (1996) [Pubmed]
  18. Specificity of Zea mays histone deacetylase is regulated by phosphorylation. Brosch, G., Georgieva, E.I., López-Rodas, G., Lindner, H., Loidl, P. J. Biol. Chem. (1992) [Pubmed]
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