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Gene Review

par-6  -  Protein PAR-6

Caenorhabditis elegans

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High impact information on par-6

  • Mutations in two of these genes, par-3 and par-6, exhibit similar phenotypes [1].
  • In addition, we find that loss-of-function par-6 mutations act as dominant bypass suppressors of loss-of-function mutations in par-2 [2].
  • The early phenotypes of par-6 embryos include the generation of equal-sized blastomeres, improper localization of P granules and SKN-1 protein, and abnormal second division cleavage patterns [2].
  • We find that mutants that disrupt anterior-posterior asymmetry in the early embryo (par-1-par-6, emb-8, Par(q537)) disrupt the spatial but not temporal control of GLP-1 expression: GLP-1 is observed at the normal stage of embryogenesis in par-like mutants; however, it is uniformly distributed [3].


  1. PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos. Hung, T.J., Kemphues, K.J. Development (1999) [Pubmed]
  2. par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3. Watts, J.L., Etemad-Moghadam, B., Guo, S., Boyd, L., Draper, B.W., Mello, C.C., Priess, J.R., Kemphues, K.J. Development (1996) [Pubmed]
  3. Genes required for GLP-1 asymmetry in the early Caenorhabditis elegans embryo. Crittenden, S.L., Rudel, D., Binder, J., Evans, T.C., Kimble, J. Dev. Biol. (1997) [Pubmed]
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