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Gene Review

par-1  -  Protein PAR-1

Caenorhabditis elegans

 
 
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High impact information on par-1

  • They encode Ser/Thr kinases of 88 and 81 kDa, respectively, and show similarity to the yeast kin1+ and C. elegans par-1 genes that are involved in the establishment of cell polarity [1].
  • Four mutations in par-1 and par-4 are fully expressed maternal effect lethal mutations; all embryos from mothers homozygous for these mutations arrest as amorphous masses of differentiated cells but are specifically lacking intestinal cells [2].
  • We find that PAL-1 is not expressed in par-1 mutants, because MEX-3 and MEX-6 remain active in the posterior blastomeres [3].
  • Ten years ago, par-1 and par-3 were cloned as two of the six par genes essential for the asymmetric division of the Caenorhabditis elegans zygote [4].
  • Genomic organization and expression analysis for hcstk, a serine/threonine protein kinase gene of Haemonchus contortus, and comparison with Caenorhabditis elegans par-1 [5].
 

Biological context of par-1

  • 14-3-3 mutants display identical phenotypes to par-1 mutants in oocyte determination and the polarization of the A-P axis [6].

References

  1. MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Drewes, G., Ebneth, A., Preuss, U., Mandelkow, E.M., Mandelkow, E. Cell (1997) [Pubmed]
  2. Identification of genes required for cytoplasmic localization in early C. elegans embryos. Kemphues, K.J., Priess, J.R., Morton, D.G., Cheng, N.S. Cell (1988) [Pubmed]
  3. MEX-3 interacting proteins link cell polarity to asymmetric gene expression in Caenorhabditis elegans. Huang, N.N., Mootz, D.E., Walhout, A.J., Vidal, M., Hunter, C.P. Development (2002) [Pubmed]
  4. The PAR-aPKC system: lessons in polarity. Suzuki, A., Ohno, S. J. Cell. Sci. (2006) [Pubmed]
  5. Genomic organization and expression analysis for hcstk, a serine/threonine protein kinase gene of Haemonchus contortus, and comparison with Caenorhabditis elegans par-1. Nikolaou, S., Hartman, D., Nisbet, A.J., Presidente, P.J., Gasser, R.B. Gene (2004) [Pubmed]
  6. Drosophila 14-3-3/PAR-5 is an essential mediator of PAR-1 function in axis formation. Benton, R., Palacios, I.M., St Johnston, D. Dev. Cell (2002) [Pubmed]
 
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