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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

mab-9  -  Protein MAB-9

Caenorhabditis elegans

 
 
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High impact information on mab-9

  • Caenorhabditis elegans mab-9 mutants are defective in hindgut and male tail development because of cell fate transformations in two posterior blast cells, B and F. We have cloned mab-9 and show that it encodes a member of the T-box family of transcriptional regulators [1].
  • Mutations in the C. elegans mab-9 gene cause massive defects in the male tail because of failed fate decisions in two tail progenitor cells [2].
  • Ce-tbx-11 and Ce-tbx-17 were uncovered through the sequencing efforts of the C. elegans Genome Project. Ce-tbx-12 was uncovered through degenerate PCR analysis of C. elegans genomic DNA [3].
  • In contrast, Ce-tbx-12 maps alone to chromosome II [3].

References

  1. The caenorhabditis elegans fate-determining gene mab-9 encodes a T-box protein required to pattern the posterior hindgut. Woollard, A., Hodgkin, J. Genes Dev. (2000) [Pubmed]
  2. Homologous tails? Or tales of homology? McGhee, J.D. Bioessays (2000) [Pubmed]
  3. Three novel T-box genes in Caenorhabditis elegans. Agulnik, S.I., Ruvinsky, I., Silver, L.M. Genome (1997) [Pubmed]
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