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Gene Review

eat-2  -  Protein EAT-2

Caenorhabditis elegans

 
 
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Psychiatry related information on eat-2

 

High impact information on eat-2

  • While eat-2 appears to be required specifically for MC neurotransmission, eat-18 also appears to be required for the function of other nicotinic receptors in the pharynx [1].
  • eat-2 and eat-18 are required for nicotinic neurotransmission in the Caenorhabditis elegans pharynx [1].
  • Axenic culture also caused higher activities of the antioxidant enzymes superoxide dismutase and catalase, and led to increased resistance to high temperature, which was further exacerbated by mutation in eat-2 [2].
  • Metabolic rate was not reduced when we fed wild-type worms reduced food and was up-regulated in the eat-2 mutants in liquid culture, as assessed by oxygen consumption rate and heat production [3].
  • Conversely, aak-2 was not required for lifespan extension in mutants lacking germline stem cells (glp-1) or mutants of the eating response (eat-2) [4].

References

  1. eat-2 and eat-18 are required for nicotinic neurotransmission in the Caenorhabditis elegans pharynx. McKay, J.P., Raizen, D.M., Gottschalk, A., Schafer, W.R., Avery, L. Genetics (2004) [Pubmed]
  2. Axenic growth up-regulates mass-specific metabolic rate, stress resistance, and extends life span in Caenorhabditis elegans. Houthoofd, K., Braeckman, B.P., Lenaerts, I., Brys, K., De Vreese, A., Van Eygen, S., Vanfleteren, J.R. Exp. Gerontol. (2002) [Pubmed]
  3. No reduction of metabolic rate in food restricted Caenorhabditis elegans. Houthoofd, K., Braeckman, B.P., Lenaerts, I., Brys, K., De Vreese, A., Van Eygen, S., Vanfleteren, J.R. Exp. Gerontol. (2002) [Pubmed]
  4. Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways. Curtis, R., O'Connor, G., DiStefano, P.S. Aging Cell (2006) [Pubmed]
 
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