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Gene Review:

eat-18 - EATing: abnormal pharyngeal pumping

Caenorhabditis elegans

This record was discontinued.

McKay, J.P. et al., Raizen, D.M. et al.

McKay, Raizen, Gottschalk, Schafer, Avery,

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Psychiatry related information on eat-18

Mutations in eat-2 and eat-18 cause the same defect in C. elegans feeding behavior: the pharynx is unable to pump rapidly in the presence of food [1].

High impact information on eat-18

While eat-2 appears to be required specifically for MC neurotransmission, eat-18 also appears to be required for the function of other nicotinic receptors in the pharynx [1].
eat-2 and eat-18 are required for nicotinic neurotransmission in the Caenorhabditis elegans pharynx [1].
It is localized to the synapse between pharyngeal muscle and the main pharyngeal excitatory motor neuron MC, and it is required for MC stimulation of pharyngeal muscle. eat-18 encodes a small protein that has no homology to previously characterized proteins [1].
A gain-of-function eat-18 mutation, ad820sd, and a putative loss-of-function eat-18 mutation, ad1110, both reduced the excitation of pharyngeal muscle in response to the nAChR agonists nicotine and carbachol, suggesting that eat-18 is required for the function of a pharyngeal nAChR [2].

References

eat-2 and eat-18 are required for nicotinic neurotransmission in the Caenorhabditis elegans pharynx. McKay, J.P., Raizen, D.M., Gottschalk, A., Schafer, W.R., Avery, L. Genetics (2004) [Pubmed]
Interacting genes required for pharyngeal excitation by motor neuron MC in Caenorhabditis elegans. Raizen, D.M., Lee, R.Y., Avery, L. Genetics (1995) [Pubmed]

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