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Gene Review

tir-1  -  Protein TIR-1

Caenorhabditis elegans

 
 
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Disease relevance of tir-1

  • Expression of two of these peptides, NLP-29 and NLP-31, was differentially regulated by fungal and bacterial infection and was controlled in part by tir-1, which encodes an ortholog of SARM, a Toll-interleukin 1 receptor (TIR) domain protein [1].
 

Psychiatry related information on tir-1

 

High impact information on tir-1

References

  1. TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM. Couillault, C., Pujol, N., Reboul, J., Sabatier, L., Guichou, J.F., Kohara, Y., Ewbank, J.J. Nat. Immunol. (2004) [Pubmed]
  2. A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling. Chuang, C.F., Bargmann, C.I. Genes Dev. (2005) [Pubmed]
  3. Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. Liberati, N.T., Fitzgerald, K.A., Kim, D.H., Feinbaum, R., Golenbock, D.T., Ausubel, F.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
 
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